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Description
RYR1 Recombinant Rabbit mAb (S-2026-22)Product Specification Host Rabbit Antigen RYR1 Synonyms Ryanodine receptor 1; RYR 1; RyR1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle type ryanodine receptor; Type 1 ryanodine receptor; RYDR Immunogen Synthetic Peptide Accession P21817 Clone Number S 2026 22 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample mouse skeletal muscle, rat skeletal muscle
Product Specification
| Host | Rabbit |
| Antigen | RYR1 |
| Synonyms | Ryanodine receptor 1; RYR-1; RyR1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor; RYDR |
| Immunogen | Synthetic Peptide |
| Accession | P21817 |
| Clone Number | S-2026-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse skeletal muscle, rat skeletal muscle |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
The RYR1 protein, or Ryanodine Receptor 1, is a crucial calcium release channel found primarily in the sarcoplasmic reticulum of skeletal muscle cells. It plays a vital role in excitation-contraction coupling by releasing calcium ions from the sarcoplasmic reticulum when activated, which then bind to troponin, leading to muscle contraction. Mutations in the RYR1 gene can lead to various muscle disorders, including malignant hyperthermia, a severe and potentially life-threatening condition triggered by certain anesthetics, and central core disease, a congenital myopathy characterized by muscle weakness and structural abnormalities in muscle fibers. The RYR1 receptor is a large, complex protein with multiple binding sites and regulatory mechanisms, making it a critical target for understanding muscle function and developing treatments for related diseases.
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