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Description
c-IAP2 Recombinant Rabbit mAb (S-3395)Product Specification Host Rabbit Antigen c IAP2 Synonyms Baculoviral IAP repeat containing protein 3; Apoptosis inhibitor 2 (API2); Cellular inhibitor of apoptosis 2 (C IAP2); IAP homolog C; Inhibitor of apoptosis protein 1 (hIAP 1; hIAP1); RING finger protein 49; API2; MIHC; RNF49; BIRC3 Location Cytoplasm, Nucleus Accession Q13489 Clone Number S 3395 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample Raji,
Product Specification
| Host | Rabbit |
| Antigen | c-IAP2 |
| Synonyms | Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2 (API2); Cellular inhibitor of apoptosis 2 (C-IAP2); IAP homolog C; Inhibitor of apoptosis protein 1 (hIAP-1; hIAP1); RING finger protein 49; API2; MIHC; RNF49; BIRC3 |
| Location | Cytoplasm, Nucleus |
| Accession | Q13489 |
| Clone Number | S-3395 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | Raji, Ramos, Daudi |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
Background
Cellular inhibitor of apoptosis protein 2 (c-IAP2, gene BIRC3) is a 618-residue member of the IAP family containing three N-terminal baculoviral IAP repeat (BIR) domains that bind caspases, a central caspase-recruitment domain (CARD) that auto-inhibits its own ubiquitin-ligase activity, and a C-terminal RING domain that endows potent E3 ubiquitin-ligase activity; through this enzymatic function c-IAP2 polyubiquitinates receptor-interacting protein 1 (RIP1) and NF-κB-inducing kinase (NIK), thereby driving canonical NF-κB prosurvival signaling while suppressing non-canonical NF-κB activation, controls TNF-α-mediated apoptosis, regulates innate immunity downstream of Toll-like and NOD-like receptors, and is frequently amplified or over-expressed in multiple cancers where its anti-apoptotic activity contributes to chemoresistance, making it a prime target for small-molecule Smac mimetics that induce its autoubiquitination and proteasomal degradation.
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