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Description
TNF alpha Recombinant Rabbit mAb (S-2506-69)Product Specification Host Rabbit Antigen TNF alpha Synonyms Tumor necrosis factor; Cachectin; TNF alpha; Tumor necrosis factor ligand superfamily member 2 (TNF a); TNFA; TNFSF2; TNF Immunogen Synthetic Peptide Location Cell membrane, Secreted Accession P01375 Clone Number S 2506 69 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | TNF alpha |
| Synonyms | Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2 (TNF-a); TNFA; TNFSF2; TNF |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Secreted |
| Accession | P01375 |
| Clone Number | S-2506-69 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
| ICC | 1:500 | Hu |
Background
Tumor necrosis factor alpha (TNF-α) is a pleiotropic, 17-kDa homotrimeric cytokine synthesized chiefly by activated macrophages but also by T cells, NK cells, fibroblasts, and adipocytes; it signals through two distinct receptors, TNFR1 and TNFR2, to orchestrate a vast array of biological processes including activation of NF-κB and MAPK pathways that drive pro-inflammatory gene expression, induction of fever, chemokine secretion for leukocyte recruitment, enhancement of cytotoxic CD8+ T cell responses, and promotion of apoptosis or necroptosis via caspase-8 or RIPK1/RIPK3 signaling, while also mediating cachexia and insulin resistance in chronic inflammation, and its dysregulated overproduction is a central driver of rheumatoid arthritis, inflammatory bowel disease, psoriasis, sepsis, and neurodegeneration, making it a prime therapeutic target for monoclonal antibodies such as infliximab, adalimumab, and certolizumab pegol.
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Exchange/Return Notes
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