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Description
PCSK9 His Tag Protein, MouseProduct Specification Species Mouse Synonyms PCSK9, FH3, PC9, FHCL3 Accession Q80W65 Amino Acid Sequence Gln35 Gln694, with C terminal 10* His Tag
Product Specification
| Species | Mouse |
| Synonyms | PCSK9, FH3, PC9, FHCL3 |
| Accession | Q80W65 |
| Amino Acid Sequence | Gln35-Gln694, with C-terminal 10* His Tag QDEDGDYEELMLALPSQEDGLADEAAHVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNAACRHLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAAHVAGIVARMLSREPTLTLAELRQRLIHFSTKDVINMAWFPEDQQVLTPNLVATLPPSTHETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDWIEAIGGQQVCKALNAFGGEGVYAVARCCLVPRANCSIHNTPAARAGLETHVHCHQKDHVLTGCSFHWEVEDLSVRRQPALRSRRQPGQCVGHQAASVYASCCHAPGLECKIKEHGISGPSEQVTVACEAGWTLTGCNVLPGASLTLGAYSVDNLCVARVHDTARADRTSGEATVAAAICCRSRPSAKASWVQGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 60-68kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Jaén R I. et al. (2022) Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release. Int J Mol Sci. 23(16): 9114. |
Background
PCSK9 (proprotein convertase subtilisin-kexin type 9) is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. PCSK9 undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism.
Atherosclerosis is a cardiovascular disease caused mainly by dyslipidemia and is characterized by the formation of an atheroma plaque and chronic inflammation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that induces the degradation of the LDL receptor (LDLR), which contributes to increased levels of LDL cholesterol and the progress of atherosclerosis.
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4.3 ★★★★★
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Product Reviews
★★★★★ 5
Quality and affordable Swiss chronometer.
Color: Silver
This is a basic but certified accurate watch which is what I wanted. It is a very good looking watch and shows quality at every level.
I have had it for seven days now and it has gained between 7 or 8 seconds which exceeds the certification standard. If it maintains this level of accuracy it will far exceed my expectations.
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Reviewed in the United States on August 8, 2023
★★★★★ 5
Excellent
Color: Gold
Pure class!
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Reviewed in the United States on November 16, 2024
★★★★★ 5
King of Mido watches
Color: Gold
Really gorgeous piece of machinery excellent keeping time and looks and feels awesome,5 stars.
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Reviewed in the United States on January 10, 2024
★★★★★ 5
Excelent
Color: Silver
Very nice 😊
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Reviewed in the United States on July 6, 2023
★★★★★ 5
Comprar la correa
Color: Gold, Color: Gold
Me compré este reloj mido commander pero se me quebró la correa metálica dorada donde la puedo comprar se quebró donde va el perno de la tapa gracias por su información
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Reviewed in the United States on August 17, 2025
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