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Description
IL-2 Protein, RatProduct Specification Species Rat Synonyms Interleukin 2; IL 2; T cell growth factor; TCGF; Aldesleukin; IL2 Accession P17108 Amino Acid Sequence Ala21 Gln155 ,at the C terminus 6His tag Expression System HEK293 Molecular Weight 14 16 KDa, reducing conditions Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 5mM NaH2PO4, 5mM Citric acid, 150mM NaCl, pH 4. 0. Stability & Storage
Product Specification
| Species | Rat |
| Synonyms | Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin; IL2 |
| Accession | P17108 |
| Amino Acid Sequence | Ala21-Gln155 ,at the C-terminus 6His tag |
| Expression System | HEK293 |
| Molecular Weight | 14-16 KDa, reducing conditions |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 5mM NaH2PO4, 5mM Citric acid, 150mM NaCl, pH 4.0. |
| Stability & Storage | Store at ≤-70°C, stable for 6 months after receipt. |
Background
Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.
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