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Description
Biotinylated CD73/NT5E Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms CD73,NT5E,5' Nucleotidase,5' NT,NTE,NT5,CALJA Accession P21589 1 Amino Acid Sequence Trp27 Ser549 with Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 90 100kDa (Reducing) Purity 90% by SDS PAGE Conjugation Biotin Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Human |
| Synonyms | CD73,NT5E,5'-Nucleotidase,5'-NT,NTE,NT5,CALJA |
| Accession | P21589-1 |
| Amino Acid Sequence | Trp27-Ser549 with Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 90-100kDa (Reducing) |
| Purity | ＞90% by SDS-PAGE |
| Conjugation | Biotin |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Stange K, Wolter T, Fu Z, Burdeos G, Mideksa Y, Friese A, Röntgen M. Isolation of Porcine Umbilical Cord Cells by Mechanical Tissue Dissociation Using a Tissue Grinder. Cells. 2025 Sep 11;14(18):1425. |
Background
CD73, or ecto-5'-nucleotidase, is an enzyme encoded by the NT5E gene, forming a homodimer of two 70-kD subunits anchored to the plasma membrane's exterior. Its principal function is the conversion of extracellular AMP to adenosine, a key signaling molecule, distinguishing it from intracellular 5'-nucleotidases. Clinically, CD73 is a vital marker for lymphocyte differentiation, and its deficiency is linked to various immunodeficiency diseases, highlighting its role in immune function. Furthermore, rare mutations in the NT5E gene cause a distinct pathology known as adult-onset calcification of joints and arteries (CALJA). This syndrome involves calcification of the iliac, femoral, and tibial arteries, leading to impaired circulation in the legs and pain in the joints of the hands and feet. Therefore, CD73 is critically positioned at the intersection of purinergic signaling and human disease, with implications spanning from its fundamental role in generating adenosine to its clinical significance in immune deficiencies and vascular calcification disorders, making it a relevant biomarker and potential therapeutic target.
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