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Description
Human LAIR1/CD305 Protein, His tagProduct Specification Species Human Synonyms Leukocyte associated immunoglobulin like receptor 1, LAIR 1, hLAIR1, CD305, LAIR1 Accession Q6GTX8 Amino Acid Sequence Protein sequence (Q6GTX8, Gln22 His163, with C His tag) QEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCIYYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEH Expression System HEK293 Molecular Weight Predicted MW: 17. 2 kDa Observed MW: 30 kDa Purity
Product Specification
| Species | Human |
| Synonyms | Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305, LAIR1 |
| Accession | Q6GTX8 |
| Amino Acid Sequence | Protein sequence (Q6GTX8, Gln22-His163, with C-His tag) QEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCIYYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEH |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 17.2 kDa Observed MW: 30 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | with C-His tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
LAIR1 (Leukocyte-Associated Immunoglobulin-like Receptor 1) is an inhibitory immune receptor primarily expressed on myeloid cells and lymphocytes. It regulates immune responses by transmitting inhibitory signals through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) upon binding to ligands like collagen or other extracellular matrix components. LAIR1 modulates inflammation, autoimmunity, and antitumor immunity, acting as a checkpoint to prevent excessive immune activation.
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