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Description
UQCRC2 Recombinant Rabbit mAb (S-1890-227)Product Specification Host Rabbit Antigen UQCRC2 Synonyms Cytochrome b c1 complex subunit 2, mitochondrial; Complex III subunit 2; Core protein II; Ubiquinol cytochrome c reductase complex core protein 2 Immunogen Synthetic Peptide Location Mitochondrion Accession P22695 Clone Number S 1890 227 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, HepG2, Ramos, HCT 116, Neuro 2a, mouse
Product Specification
| Host | Rabbit |
| Antigen | UQCRC2 |
| Synonyms | Cytochrome b-c1 complex subunit 2, mitochondrial; Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P22695 |
| Clone Number | S-1890-227 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, HepG2, Ramos, HCT 116, Neuro-2a, mouse heart, C6, rat heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
UQCRC2 (ubiquinol-cytochrome c reductase core protein 2), encoded on chromosome 16p12.2, is a 453-amino-acid, 48.4 kDa integral component of mitochondrial complex III (cytochrome b-c1 complex) that stabilizes the ~450 kDa multisubunit transmembrane assembly and, by facilitating electron flow from ubiquinol to cytochrome c coupled to proton pumping across the inner membrane, powers the electrochemical gradient essential for oxidative phosphorylation, while its peptidase-M16-family processing activity contributes to maturation of the Rieske iron-sulfur protein and mutations in UQCRC2 are linked to mitochondrial complex III deficiency nuclear type 5.
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