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Description
TrkC mFc Chimera Protein, MouseProduct Specification Species Mouse Synonyms TrkC, Ntrk3, AW125844 Accession Q6VNS1 Amino Acid Sequence Cys32 Thr429, with C terminal mIgG2a Fc
Product Specification
| Species | Mouse |
| Synonyms | TrkC, Ntrk3, AW125844 |
| Accession | Q6VNS1 |
| Amino Acid Sequence | Cys32-Thr429, with C-terminal mIgG2a Fc CPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCSCDIRWMQLWQEQGEARLDSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLVEPEVRLEHCIEFVVRGNPTPTLHWLYNGQPLRESKIIHMDYYQEGEVSEGCLLFNKPTHYNNGNYTLIAKNALGTANQTINGHFLKEPFPESTDFFDFESDASPTPPITVTHKPEEDTIEGRMDPEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK |
| Expression System | HEK293 |
| Molecular Weight | 95-125kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Mouse Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Khotskaya Y B. et al. (2017) Targeting TRK family proteins in cancer. Pharmacol Ther. 173: 58-66. |
Background
The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins, which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of neurotrophins to TRK proteins induces receptor dimerization, phosphorylation, and activation of the downstream signaling cascades via PI3K, RAS/MAPK/ERK, and PLC-gamma. TrkC functions not only as an oncogene, but also act as a tumor suppressor via a manner of dependence receptor in human malignant tumors. TrkC is a potent oncoprotein expressed in tumors derived from multiple cell lineages, and functions as an active protein tyrosine kinase by neurotrophin-3 (NT-3).
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4.8 ★★★★★
Based on 20 reviews
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Product Reviews
★★★★★ 5
Excellent
Size: X-Large, Color: (025) Castlerock / Castlerock / Anthracite
Excellent product
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Reviewed in the United States on March 17, 2026
★★★★★ 5
Fit great
Size: Large, Color: (100) White / White / Halo Gray
Been a couple of months and they seem to be holding up nicely. Real picky about fit of socks and these fit well. They are very thin but very comfortable.
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Reviewed in the United States on October 21, 2024
★★★★★ 5
Always a win
Size: Large, Color: (001) Black / Black / Castlerock
Under armor is always a win! Comfortable, no peeling, true to size, no squeezing around the arch of foot & affordable.
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Reviewed in the United States on January 4, 2026
★★★★★ 4
Fit well and stay up
Size: Large, Color: (299) City Khaki / City Khaki / White
They're a little thin, so good mainly for warmer months. But they fit very well and I've not experienced any slippage
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Reviewed in the United States on March 17, 2026
★★★★★ 5
Llego a tiempo
Size: X-Large, Color: (001) Black / Black / Castlerock
Bien
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Reviewed in the United States on April 28, 2026