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Description
MYH7 Recombinant Rabbit mAb (SDT-2936-44)Product Specification Host Rabbit Antigen MYH7 Synonyms Myosin 7; Myosin heavy chain 7; Myosin heavy chain slow isoform (MyHC slow); Myosin heavy chain; cardiac muscle beta isoform (MyHC beta); MYHCB Immunogen Synthetic Peptide Location Cytoplasm Accession P12883 Clone Number SDT 2936 44 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 25 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | MYH7 |
| Synonyms | Myosin-7; Myosin heavy chain 7; Myosin heavy chain slow isoform (MyHC-slow); Myosin heavy chain; cardiac muscle beta isoform (MyHC-beta); MYHCB |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P12883 |
| Clone Number | SDT-2936-44 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:2000 | Hu, Ms, Rt |
| IF | 1:1000-1:2000 | Hu, Ms, Rt |
Background
MYH7, the slow/cardiac β-myosin heavy chain encoded by the MYH7 gene on chromosome 14q12, is the dominant motor protein of the human ventricle and type I skeletal muscle fibers, forming the hexameric thick-filament complex (two MYH7, two ELC, two RLC) whose ATP-driven conformational cycles generate ≈2 pN of force at 5–10 nm steps; pathogenic missense or truncating variants disrupt this chemomechanical cycle and the accompanying α-helical coiled-coil packing, producing a dosage-sensitive spectrum of disease—hypertrophic and dilated cardiomyopathy, myosin storage myopathy, Laing distal myopathy—characterized by hypertrophic sarcomeres, replacement fibrosis, and progressive heart or skeletal muscle failure, while physiologically MYH7 expression is induced by thyroid hormone, exercise, and β-adrenergic signaling that up-regulate slow oxidative programs, making the protein a central therapeutic target for small-molecule myosin inhibitors (mavacamten) and gene-editing strategies aimed at normalizing contractile kinetics and Ca²⁺ sensitivity.
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