SKU: 93278696943

Invivo anti-Mouse Ly6C Recombinant mAb

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Description

Invivo anti-Mouse Ly6C Recombinant mAbProduct Specification Host Rat Antigen Ly 6C Synonyms Lymphocyte antigen 6C1; Ly 6C1; Ly6c1 Location Cell membrane Accession P0CW02 Clone Number S 4036 Antibody Type Rat mAb Application FCM, in vivo macrophage depletion Reactivity Ms Purification Protein G Concentration 5 mg ml Purity >95%(Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no preservative Stability &

Product Specification


Host Rat
Antigen Ly-6C
Synonyms Lymphocyte antigen 6C1; Ly-6C1; Ly6c1
Location Cell membrane
Accession P0CW02
Clone Number S-4036
Antibody Type Rat mAb
Application FCM, in vivo macrophage depletion
Reactivity Ms
Purification Protein G
Concentration 5 mg/ml
Purity >95%(Determined by SDS-PAGE)
Endotoxin <1EU/mg
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, containing no preservative

Stability & Storage

2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.

Background

Ly-6C is a glycosylphosphatidylinositol-anchored cell-surface protein belonging to the Ly-6/uPAR/α-neurotoxin superfamily, selectively expressed on murine monocyte and T-cell subsets where it serves as a dynamic lineage and activation marker—its high level on pro-inflammatory “classical” monocytes (CD11b⁺Ly-6C^hi) enables their recruitment via CCR2 to inflamed tissues, whereas Ly-6C^lo monocytes patrol vasculature and replenish resident macrophages, and transient up-regulation on CD8⁺ T cells correlates with effector differentiation; structurally it forms a three-finger α-helical bundle that can laterally associate with lipid rafts and signaling partners such as T-cell receptor or integrin complexes to modulate calcium flux, cytokine release, and adhesion, thereby critically steering innate–adaptive immune crosstalk in infections, autoimmunity, and cardiovascular disease.

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SKU: 93278696943

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4.0 ★★★★★
Based on 17 reviews
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E
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Edward Davidson
Carnegie, US
★★★★★ 4
Great ball but poor squeaked design
Size: 4.5"
My Rottie loves these balls. The ball lasts a long time even though he plays hard and chews them. My biggest complaint is the squeaker disconnects easily from inside the ball, the glue does not hold! We have bought many of these balls because eventually the area where the squeaker is attached comes away from the ball leaving an open whole that causes the ball to eventually developed a long crack at which point it no longer is able to be thrown nor is is fun for him any longer.
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Reviewed in the United States on December 19, 2025
A
Verified Purchase
A. Estrella
Alexandria, US
★★★★★ 5
Well made and great fun for our Pittie
Size: 4.5"
My pittie loves these! They are way thicker than others. He has learned how to chew on the spikes. Seems like a good teeth cleaning too. Yes, the squeaker breaks! That is a great thing!! With his active chewing, that sound was driving us crazy after a while.
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Reviewed in the United States on February 19, 2026
D
Verified Purchase
Donald
Dallas, US
★★★★★ 5
"Durable Fun: Pweituoet Heavy Duty Squeaky Dog Balls for Aggressive Chewers"
Size: 4.5"
Product Review: The Pweituoet 4.5” Heavy Duty Squeaky Dog Balls have been a hit with my dog, proving to be both durable and entertaining. Durability: These dog balls are impressively tough. My dog is an aggressive chewer, and most toys don’t last long, but these balls have held up exceptionally well. The heavy-duty material and spiked design are perfect for dogs who love to chew, providing both durability and safety. Entertainment: The built-in squeaker adds an extra layer of fun. It captures my dog’s attention immediately, and the squeak keeps him engaged for longer play sessions. The spikes also make the ball easy for him to grip and carry around. Size: The 4.5” size is ideal for medium to large dogs. It’s large enough to avoid being a choking hazard but still easy for my dog to pick up and play with. The size and weight are just right for games of fetch, too. Value: Given the durability and how much my dog enjoys these balls, they offer great value for the price. They’ve lasted much longer than other toys we’ve tried, making them a worthwhile investment for any dog owner with a tough chewer. Overall Verdict: The Pweituoet Heavy Duty Squeaky Dog Balls are an excellent choice for medium to large dogs, especially those who are aggressive chewers. They’re durable, fun, and well-sized, making them a great addition to your dog’s toy collection. Highly recommended!
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Reviewed in the United States on August 10, 2024
C
Verified Purchase
Chris Wells
Waukegan, US
★★★★★ 5
Actually stands up to use
Size: 4.5", Size: 4.5"
I have a pitbull who is a toy destroyer. All those toys, even the ones that say tough enough for destroyers, never hold up. THESE BALLS ARE AWESOME! I bought the 2 pack of the 4.5 inch balls and they lasted a year. I literally am writing this review after ordering a new set. These are well worth the money and Ghost (my dog) loves them. Hes a 103lbs pitbull and his life mission is cuddles and destroying his toys... and these lasting a year of everyday use is friggin awesome. Both toys failed in the same way eventually. They gave out in a circle around the "squeker".
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Reviewed in the United States on September 14, 2024
C
Verified Purchase
CFM
Phoenix, US
★★★★★ 3
Neutral
Size: 4.5"
She chewed it up in less than 10 minutes. This is not for heavy chewers but dogs that like to actually play with their toys it would be great!!! I gave it a 3 because it worked for my other dog who likes to play🤘
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Reviewed in the United States on March 8, 2026

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