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Description
Progranulin Recombinant Rabbit mAb (S-2202-46)Product Specification Host Rabbit Antigen Progranulin Synonyms Progranulin; PGRN; Acrogranin; Epithelin precursor; Glycoprotein of 88 Kda (GP88; Glycoprotein 88); Granulin precursor; PC cell derived growth factor (PCDGF); Proepithelin (PEPI); GRN Immunogen Recombinant Protein Location Secreted, Lysosome Accession P28799 Clone Number S 2202 46 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HeLa, A431,
Product Specification
| Host | Rabbit |
| Antigen | Progranulin |
| Synonyms | Progranulin; PGRN; Acrogranin; Epithelin precursor; Glycoprotein of 88 Kda (GP88; Glycoprotein 88); Granulin precursor; PC cell-derived growth factor (PCDGF); Proepithelin (PEPI); GRN |
| Immunogen | Recombinant Protein |
| Location | Secreted, Lysosome |
| Accession | P28799 |
| Clone Number | S-2202-46 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HeLa, A431, HepG2, A549 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
Background
Progranulin is a multifunctional protein that plays crucial roles in various biological processes. It is highly expressed in numerous tissues and is involved in cell growth, differentiation, and survival. Progranulin acts as a growth factor, promoting the proliferation of epithelial cells and fibroblasts. It also has anti-inflammatory properties, modulating immune responses by inhibiting the production of pro-inflammatory cytokines. Additionally, progranulin is implicated in the maintenance of tissue homeostasis and repair, particularly in the brain and nervous system. Mutations in the progranulin gene have been linked to neurodegenerative diseases such as frontotemporal dementia, highlighting its importance in neuronal health.
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