Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Sep 19 - Sep 24
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
AIFM2/FSP1 Recombinant Rabbit mAb (S-2271-67)Product Specification Host Rabbit Antigen AIFM2 FSP1 Synonyms Ferroptosis suppressor protein 1; Apoptosis inducing factor homologous mitochondrion associated inducer of death (AMID); p53 responsive gene 3 protein; AMID; PRG3 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Mitochondrion, Cell membrane Accession Q9BRQ8 Clone Number S 2271 67 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms Positive Sample HeLa,
Product Specification
| Host | Rabbit |
| Antigen | AIFM2/FSP1 |
| Synonyms | Ferroptosis suppressor protein 1; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death (AMID); p53-responsive gene 3 protein; AMID; PRG3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Mitochondrion, Cell membrane |
| Accession | Q9BRQ8 |
| Clone Number | S-2271-67 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa, MCF7, A172, NIH/3T3, mouse kidney, mouse liver |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:200 | Hu, Ms |
Background
AIFM2, also known as ferroptosis suppressor protein 1 (FSP1), apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID), or p53-responsive gene 3 (PRG3), is a protein encoded by the AIFM2 gene in humans. It is a flavoprotein oxidoreductase that plays a crucial role in regulating ferroptosis, a form of cell death characterized by iron-dependent lipid peroxidation. FSP1 primarily localizes to the plasma membrane and lipid droplets, and it suppresses ferroptosis by reducing ubiquinone (CoQ10) to ubiquinol (CoQ10-H2) using NAD(P)H as a cofactor, thereby preventing lipid peroxidation. This protein is also involved in the reduction of other molecules, such as vitamin K, and has been implicated in tumorigenesis and resistance to therapy in certain cancer models.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy