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Description
Brachyury Recombinant Rabbit mAb,PBS Only (SDT-1926-107)Product Specification Host Rabbit Antigen Brachyury Synonyms T box transcription factor T; Brachyury protein; Protein T; T; TBXT Immunogen Recombinant Protein Location Nucleus Accession O15178 Clone Number SDT 1926 107 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin
Product Specification
| Host | Rabbit |
| Antigen | Brachyury |
| Synonyms | T-box transcription factor T; Brachyury protein; Protein T; T; TBXT |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | O15178 |
| Clone Number | SDT-1926-107 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | Hu |
Background
Brachyury protein is a transcription factor encoded by the TBXT gene, belonging to the T-box family of genes. It plays a crucial role in embryonic development, particularly in the formation and differentiation of the mesoderm and the notochord, which is the precursor of the spinal column. In adults, Brachyury is almost exclusively expressed in notochord-derived cells. Abnormal expression of Brachyury has been associated with certain cancers, such as chordoma, a malignant tumor that arises from residual notochordal cells. Additionally, it is involved in the epithelial-mesenchymal transition (EMT) in various carcinomas, promoting tumor invasion and metastasis.
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