Mouse CXCL1/KC Onestep ELISA Kit

Mouse CXCL1, also known as KC (keratinocyte-derived chemokine), is a key member of the CXC chemokine family primarily secreted by macrophages, fibroblasts, and endothelial cells in response to pro-inflammatory stimuli such as IL-1β or TNF-α. It functions as a potent chemoattractant by binding to its receptor CXCR2, which is predominantly expressed on neutrophils, thereby orchestrating the rapid recruitment of these immune cells to sites of infection, tissue injury, or inflammation. This protein plays a critical role in acute inflammatory responses, contributing to host defense against bacterial and fungal pathogens. Beyond infection, CXCL1 is also implicated in various pathological processes including cancer progression, where it can promote tumor growth, angiogenesis, and metastasis by modulating the tumor microenvironment. Additionally, it is involved in autoimmune diseases and chronic inflammatory conditions such as rheumatoid arthritis. In experimental models, CXCL1 is widely utilized as a biomarker for neutrophilic inflammation, and it is signaling pathway is considered a potential therapeutic target for mitigating excessive inflammation or disrupting pro-tumorigenic networks.