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Description
APC Mouse Anti-Human CD16 Antibody (S-R440)Product Specification Host Mouse Antigen CD16 Synonyms Low affinity immunoglobulin gamma Fc region receptor III A; IgG Fc receptor III A; CD16 II; CD16a antigen; Fc gamma RIII alpha (Fc gamma RIII; Fc gamma RIIIa; FcRIII; FcRIIIa; FcgammaRIIIA); FcR 10; IgG Fc receptor III 2; CD16a; FCG3; FCGR3; IGFR3; FCGR3A Location Secreted, Cell membrane Accession P08637 Clone Number S R440 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu
Product Specification
| Host | Mouse |
| Antigen | CD16 |
| Synonyms | Low affinity immunoglobulin gamma Fc region receptor III-A; IgG Fc receptor III-A; CD16-II; CD16a antigen; Fc-gamma RIII-alpha (Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcgammaRIIIA); FcR-10; IgG Fc receptor III-2; CD16a; FCG3; FCGR3; IGFR3; FCGR3A |
| Location | Secreted, Cell membrane |
| Accession | P08637 |
| Clone Number | S-R440 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.2mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD16, also known as FcγRIII, is a type of glycoprotein belonging to the immunoglobulin superfamily. It is divided into two subtypes: CD16a (FcγRIIIa) and CD16b (FcγRIIIb). CD16a is a transmembrane protein mainly expressed on natural killer (NK) cells, monocytes, and some T cell subsets, while CD16b is a GPI-anchored protein primarily found on neutrophils. CD16a can mediate antibody-dependent cell cytotoxicity (ADCC) by binding to the Fc region of IgG antibodies, which is crucial for the immune system to eliminate virus-infected cells and cancer cells. Additionally, CD16a is one of the core markers for defining NK cells and can promote their proliferation and secretion of cytotoxic cytokines. In cancer immunotherapy, CD16a is an important target protein, and some monoclonal antibody drugs are designed to enhance its binding ability to boost immune responses.
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