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Description
Non-biotinylated GLP-1R His&Avi Tag, HumanProduct Specification Species Human Synonyms GLP1R, GLP 1 receptor, GLP 1 R Accession P43220 1 Amino Acid Sequence Ala21 Glu139 with His&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 25 40kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag Avi Tag, His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | GLP1R, GLP-1 receptor, GLP-1-R |
| Accession | P43220-1 |
| Amino Acid Sequence | Ala21-Glu139 with His&Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 25-40kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & HPLC |
| Conjugation | Unconjugated |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G. Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature. 2017 Jun 8;546(7657):248-253. |
Background
The GLP-1R (Glucagon-Like Peptide-1 Receptor) belongs to class B G protein-coupled receptors, comprising an N-terminal extracellular domain (ECD), seven-transmembrane helix bundle, and intracellular C-terminus. Upon binding of peptide ligands to the ECD, the receptor ECD dissociates from the transmembrane domain, TM6 and TM7 undergo significant outward displacement, and the G protein α subunit inserts into the receptor core to form a complete signaling complex. This receptor is widely expressed in pancreatic β cells, central nervous system (hypothalamus and brainstem nucleus tractus solitarius), cardiovascular system, and gastrointestinal tract. It promotes glucose-dependent insulin secretion and inhibits glucagon release through the Gs protein-cAMP-PKA pathway, while regulating appetite and energy metabolism via the brain-gut axis. Clinically, GLP-1R agonists such as semaglutide and tirzepatide (a dual GLP-1/GIP receptor agonist) not only significantly reduce HbA1c and cardiovascular event risk in type 2 diabetes patients but also achieve 15%-20% weight loss in obesity treatment. Their therapeutic applications have expanded to MASH (metabolic dysfunction-associated steatohepatitis) and Parkinson's disease, representing a major breakthrough in precision intervention for metabolic diseases.
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