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Description
GPNMB Recombinant Rabbit mAb (S-491-6)Product Specification Host Rabbit Antigen GPNMB Synonyms Transmembrane glycoprotein NMB, Hematopoietic growth factor inducible neurokinin 1 type, HGFIN, NMB Immunogen Synthetic Peptide Location Cell membrane Accession Q14956 Clone Number S 491 6 Antibody Type Recombinant mAb Application WB, IHC P, ICC, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol,
Product Specification
| Host | Rabbit |
| Antigen | GPNMB |
| Synonyms | Transmembrane glycoprotein NMB, Hematopoietic growth factor inducible neurokinin-1 type, HGFIN, NMB |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q14956 |
| Clone Number | S-491-6 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:2000 | |
| ICC | 1:50 | |
| IP | 1:50 |
Background
GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein. GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic cells, and it is overexpressed in various cancer types. GPNMB was originally identified as a gene that was expressed in poorly metastatic human melanoma cell lines and xenografts and not expressed in highly metastatic cell lines. However, several recent studies have identified high GPNMB expression in aggressive melanoma, glioma, and breast cancer specimens.
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