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Description
CD3 epsilon Mouse mAb (SDT-570-36)Product Specification Host Mouse Antigen CD3 EPSILON Synonyms T cell surface glycoprotein CD3 epsilon chain, T cell surface antigen T3 Leu 4 epsilon chain, CD3e, T3E Immunogen Recombinant Protein Location Cell membrane Accession P07766 Clone Number SDT 570 36 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P, ICC, IF Reactivity Hu Purification Protein G Concentration Lot specific* (generally 0. 2 to 2 mg ml)* Conjugation Unconjugated
Product Specification
| Host | Mouse |
| Antigen | CD3 EPSILON |
| Synonyms | T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, T3E |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P07766 |
| Clone Number | SDT-570-36 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | Lot specific* (generally 0.2 to 2 mg/ml)* |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:500 | null |
| ICC | 1:500 | null |
| IF | 1:200 | null |
Background
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex. The CD3–T cell receptor (TCR) complex plays a central role in the T-cell-mediated immunoresponse as it is involved in the recognition of antigens and subsequent signal transduction and activation of immunocompetent T lymphocytes. Because CD3 is required for T cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies (e.g., otelixizumab, teplizumab) for type 1 diabetes and other autoimmune diseases.
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