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Description
Escherichia coli MCR-1 Protein, His TagProduct Specification Synonyms Phosphatidylethanolamine transferase Mcr 1, Polymyxin resistance protein MCR 1, mcr 1 Accession A0A0R6L508 Amino Acid Sequence Protein sequence (A0A0R6L508, Try179 Arg541, with C His Tag)
Product Specification
| Synonyms | Phosphatidylethanolamine transferase Mcr-1, Polymyxin resistance protein MCR-1, mcr-1 |
| Accession | A0A0R6L508 |
| Amino Acid Sequence | Protein sequence (A0A0R6L508, Try179-Arg541, with C-His Tag) YASFFRVHKPLRSYVNPIMPIYSVGKLASIEYKKASAPKDTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 42.4 kDa Observed MW: 40 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
The MCR-1 protein, encoded by the *mcr-1* gene in Escherichia coli and other Enterobacteriaceae, is a phosphoethanolamine transferase. Its primary function is to modify the lipid A component of lipopolysaccharide (LPS) in the bacterial outer membrane by adding phosphoethanolamine. This modification significantly reduces the net negative charge of the membrane, thereby conferring resistance to colistin (polymyxin E), a last-resort antibiotic for treating multidrug-resistant Gram-negative infections. First reported in China in 2015, MCR-1 is notable because its gene is often plasmid-borne, enabling horizontal transfer between bacterial species and facilitating the rapid global spread of colistin resistance, posing a major public health threat.
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