SKU: 22026403054

E-Selectin/CD62E Fc Chimera Protein, Mouse

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Description

E-Selectin/CD62E Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms SELE, RP1 117P20. 2, ELAM1, ESEL, LECAM2 Accession Q00690 Amino Acid Sequence Trp22 Pro557, with C terminal Fc Expression System HEK293 Molecular Weight 95 125kDa (Reducing) Purity 95% by SDS PAGE & RP HPLC Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure

Product Specification


Species Mouse
Synonyms SELE, RP1-117P20.2, ELAM1, ESEL, LECAM2
Accession Q00690
Amino Acid Sequence Trp22-Pro557, with C-terminal Fc
Expression System HEK293
Molecular Weight

95-125kDa (Reducing)

Purity >95% by SDS-PAGE & RP-HPLC
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Matsumoto K, et al. (2010) Soluble adhesion molecule E-selectin predicts cardiovascular events in Japanese patients with type 2 diabetes mellitus. Metabolism. 59(3): 320-4.
2.Stancanelli B, et al. (2010) Soluble e-selectin is an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients. Nephron Clin Pract. 114(1): c74-80

Background

E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells. It is sometimes implicated in cancer cell metastasis. E-selectin features a complex mosaic structure, which includes a large extracellular region composed of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain. This is followed by a transmembrane region and a relatively short cytoplasmic tail of 32 amino acids (aa).
As a member of the selectin family, E-selectin recognizes and binds to sialylated carbohydrates, including those belonging to the Lewis X and Lewis A families, which are found on the surface of monocytes, granulocytes, and T-lymphocytes. It supports the rolling and stable arrest of leukocytes on activated vascular endothelium. Additionally, E-selectin has been shown to transduce an activating stimulus via the mitogen-activated protein kinase (MAPK) cascade into the endothelial cell during leukocyte adhesion.

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SKU: 22026403054

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