Pay in installments of $28.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Sep 15 - Sep 20
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
ROR1 His Tag Protein, CanineProduct Specification Species Canine Synonyms NTRKR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor Related 1 Accession XP_038521907. 1 Amino Acid Sequence Glu48 Tyr423, with C terminal His Expression System HEK293 Molecular Weight 55 70kDa (Reducing) Purity >95% by SDS PAGE &>95% by RP HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7.
Product Specification
| Species | Canine |
| Synonyms | NTRKR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor-Related 1 |
| Accession | XP_038521907.1 |
| Amino Acid Sequence | Glu48-Tyr423, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 55-70kDa (Reducing) |
| Purity | >95% by SDS-PAGE &>95% by RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Quezada M J. et al. (2023) The signaling pathways activated by ROR1 in cancer. Cell Signal. 104: 110588. |
Background
The receptor tyrosine kinase orphan receptor 1 (ROR1) serves as a receptor for WNT5A and related Wnt proteins, which are crucial during embryonic development. They regulate processes such as cell migration, cell polarity, neural patterning, and organogenesis. ROR1 mediates these functions by transducing signals from the Wnt secreted glycoproteins to the intracellular Wnt/PCP and Wnt/Ca++ pathways.
In adult human cells, especially in cancer cells, research has shown that the WNT5A/ROR1 axis can activate a variety of signaling pathways in addition to the aforementioned ones. These include the PI3K/AKT, MAPK, NF-κB, STAT3, and Hippo pathways. Furthermore, ROR1 is often aberrantly expressed in cancer and has been linked to tumor progression and poor patient survival outcomes. Its role in promoting cell proliferation, survival, invasion, epithelial-to-mesenchymal transition (EMT), and metastasis is significant.
As a result, ROR1 has emerged as a potential therapeutic target, and numerous tools aimed at targeting ROR1 are currently under evaluation in clinical trials for cancer patients.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy