SKU: 21095137772

PTK7/CCK4 His Tag Protein, Cynomolgus

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Description

PTK7/CCK4 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms PTK7, CCK4, Tyrosine protein kinase like 7, Protein tyrosine kinase 7, Protein tyrosine kinase 7 Accession A0A2K5VNI5 Amino Acid Sequence Ala39 Thr712, with C terminal His Expression System HEK293 Molecular Weight 90 100kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0.

Product Specification


Species Cynomolgus
Synonyms PTK7, CCK4, Tyrosine-protein kinase-like 7, Protein-tyrosine kinase 7, Protein-tyrosine kinase 7
Accession A0A2K5VNI5
Amino Acid Sequence Ala39-Thr712, with C-terminal His
Expression System HEK293
Molecular Weight 90-100kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Lichtig H. et al. (2019) Ptk7 proteolytic fragment proteins function during early xenopus development. Dev Biol. 453 (1): 48-55.

2、Damelin M. et al. (2017) A ptk7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. Sci Transl Med. 9 (372): eaag2611.

3、Berger H. et al. (2017) Ptk7 faces the wnt in development and disease. Front Cell Dev Biol. 5: 31.

Background

PTK7 comprises an extracellular region with seven immunoglobulin (Ig)-like loops, a transmembrane domain, and a cytosolic region containing a defective tyrosine kinase catalytic domain. Previous studies have reported that PTK7 functions as a co-receptor in the semaphorin/plexin signaling pathway, as well as in planar cell polarity and non-canonical Wnt signaling pathways during developmental processes. Additionally, PTK7 is associated with tumorigenesis. The expression of PTK7, which is upregulated in various malignancies, is negatively correlated with disease-free survival and/or overall survival in patients with cancer. PTK7 potentiates oncogenic signaling by functioning as a co-receptor for active RPTKs, such as FGFR1. The expression of PTK7 is also upregulated in endothelial cells, especially during tube formation.
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SKU: 21095137772

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★★★★★ 5
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DCB
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Valet Tray
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Reviewed in the United States on April 7, 2026
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Joseph Klobuchar
Massapequa, US
★★★★★ 5
Just lovely
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Purchased this several months ago and liked it, but I had received so many complements on this tray since then I had to submit this review. The tray is sturdy and put together well, and the size is exactly what was given before purchase.
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Reviewed in the United States on May 27, 2026
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Anonymous
Fort Morgan, US
★★★★★ 5
Useful and Handy !
Very useful
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