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Description
IMP-3 Recombinant Rabbit mAb (S-439-10)Product Specification Host Rabbit Antigen IMP 3 Synonyms Insulin like growth factor 2 mRNA binding protein 3, IGF2 mRNA binding protein 3, IGF II mRNA binding protein 3, KH domain containing protein overexpressed in cancer (hKOC), VICKZ family member 3, IGF2BP3, KOC1, VICKZ3 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession O00425 Clone Number S 439 10 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM
Product Specification
| Host | Rabbit |
| Antigen | IMP-3 |
| Synonyms | Insulin-like growth factor 2 mRNA-binding protein 3, IGF2 mRNA-binding protein 3, IGF-II mRNA-binding protein 3, KH domain-containing protein overexpressed in cancer (hKOC), VICKZ family member 3, IGF2BP3, KOC1, VICKZ3 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | O00425 |
| Clone Number | S-439-10 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:200 | null |
| ICC | 1:500 | null |
| ICFCM | 1:500 | null |
Background
Insulin-like growth factor-II (IGF-II) messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the IGF-II mRNA-binding protein (IMP) family, which also includes IMP-1 and IMP-2. IMP-3 is a 580 amino-acid protein encoded by a 4350-bp mRNA transcript produced by a gene located on chromosome 7p11.5. As a translational activator of IGF-II leader-3 mRNA, it is associated with cell proliferation and is considered an oncofetal protein due to its expression during embryogenesis and in some malignancies. Normal adult tissues that express IMP-3 include term placenta, ovary, testis, brain, lymph node germinal centers, and intestinal mucosa. Increased levels of IMP-3 have been identified in pancreatic carcinoma, renal cell carcinoma, germ cell neoplasms, ovarian carcinoma, and extrapulmonary small-cell carcinoma, as well as high-grade neuroendocrine carcinoma, squamous cell carcinoma, and adenocarcinoma of the lung. Additionally, IMP-3 was shown to be a prognostic marker in patients with renal cell carcinoma, with lack of expression in the primary tumor predicting longer metastases-free survival.
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