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Description
RRM1 Recombinant Rabbit mAb (S-587-21)Product Specification Host Rabbit Antigen RRM1 Synonyms Ribonucleoside diphosphate reductase large subunit, Ribonucleoside diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RR1 Immunogen Synthetic Peptide Location Cytoplasm Accession P23921 Clone Number S 587 21 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ICFCM Reactivity Hu, Ms, Rt Predicted Reactivity Or Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | RRM1 |
| Synonyms | Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RR1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P23921 |
| Clone Number | S-587-21 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Or |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:100 | |
| ICFCM | 1:50 |
Background
Ribonucleotide reductase large subunit M1 (RRM1) is a rate-limiting enzyme of the DNA synthesis pathway, and is depended on for the conversion of ribonucleotides to dNTPs. Studies have shown that increased levels of RRM1 are associated with resistance to gemcitabine. RRM1 has also been reported to affect disease prognosis of pancreatic cancer. In fact, the meta-analysis for RRM1 demonstrated that high expression of RRM1 was significantly associated with worse overall survival. The clinical impact of RRM1 has been elucidated
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