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Description
Fc γ RIIIa/CD16a(F176) His Tag Protein, HumanProduct Specification Species Human Synonyms Fc RIIIa , CD16a(F176); Low Affinity Immunoglobulin Gamma Fc Region Receptor III A, CD16a Antigen, Fc Gamma RIII Alpha, Fc Gamma RIII, Fc gamma RIIIa, FcRIII, FcRIIIa, FcR 10, IgG Fc Receptor III 2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3 Accession P08637 1 Amino Acid Sequence Gly17 Gln208(F176), with C terminal His Expression System HEK293 Molecular Weight 27 30 kDa(Reducing) Purity 95%, by SDS PAGE under
Product Specification
| Species | Human |
| Synonyms | Fc γ RIIIa , CD16a(F176);Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A, CD16a Antigen, Fc-Gamma RIII-Alpha, Fc-Gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc Receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3 |
| Accession | P08637-1 |
| Amino Acid Sequence | Gly17-Gln208(F176), with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 27 -30 kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three types: RI (CD64), RII (CD32) and RIII (CD16). CD16 is a low-affinity Fc receptor, which has been identified as Fc receptor Fc γ RIII (a (CD16a) and Fc γ RIIIb (CD16b). These receptors bind to the Fc portion of the IgG antibody and are encoded by two different highly homologous genes in a cell type-specific manner. In human, CD16a is a 50-70 kDa type I transmembrane activated receptor expressed by NK cells, T cells, monocytes and macrophages. It exists on the surface of natural killer cells, neutrophils, polymorphonuclear leukocytes, monocytes and macrophages, and participates in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity and clearance of immune complexes. Abnormal expression or mutation of CD16a is associated with recurrent viral infection, systemic lupus erythematosus and neutropenia in newborns with alloimmunity. In humans, single amino acid mutations (176V) and (176F) may affect susceptibility to autoimmune diseases or response to therapeutic IgG antibodies.
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