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Description
Human BRD4 Protein, His tagProduct Specification Species Human Synonyms Bromodomain containing protein 4, Protein HUNK1, HUNK1 Accession O60885 Amino Acid Sequence Protein sequence (O60885, Ser42 Glu168, with N His tag) STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE Expression System E. coli Molecular Weight Predicted MW: 16. 9 kDa Observed MW: 15 kDa Purity 95% by SDS PAGE Endotoxin <0. 1EU g
Product Specification
| Species | Human |
| Synonyms | Bromodomain-containing protein 4, Protein HUNK1, HUNK1 |
| Accession | O60885 |
| Amino Acid Sequence | Protein sequence (O60885, Ser42-Glu168, with N-His tag) STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 16.9 kDa Observed MW: 15 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | with N-His tag |
| Physical Appearance | Liquid |
| Storage Buffer | Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl (pH7.5), 300 mM NaCl, 5% glycerol. |
| Stability & Storage | 12 months from date of receipt, -20℃ as supplied. |
Background
Bromodomain - containing protein 4 (BRD4) is a pivotal protein in epigenetic regulation. As a member of the BET (bromodomain and extra - terminal domain) family, it binds to acetylated lysine residues on histone tails via its bromodomains. This binding enables BRD4 to recruit transcriptional co - activators, such as the positive transcription elongation factor b (P - TEFb), and facilitate the transition from transcription initiation to elongation. In normal cells, BRD4 is involved in cell cycle progression, differentiation, and development. However, in cancer, aberrant BRD4 function is frequently observed. It drives the over - expression of oncogenes, fueling tumor cell growth, proliferation, and survival.
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