SKU: 1274420893

Armenian Hamster Anti-Mouse TCR γ/δ Antibody (S-R525)

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Description

Armenian Hamster Anti-Mouse TCR γ/δ Antibody (S-R525)Product Specification Host Armenian hamster Antigen TCR Location Cell membrane Accession 110066 110067 Clone Number S R525 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied.

Product Specification


Host Armenian hamster
Antigen TCR γ/δ
Location Cell membrane
Accession 110066、 110067
Clone Number S-R525
Antibody Type Recombinant mAb
Isotype IgG
Application FCM
Reactivity Ms
Positive Sample BALB/c mouse splenocytes
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 1:200 Ms

Background

TCR γ protein is a key component of the γδ T cell receptor (TCR), which is a heterodimer comprising TCRγ and TCRδ chains. Unlike the αβ TCR, which primarily recognizes peptide antigens presented by MHC molecules, the γδ TCR can identify a diverse range of antigens in an MHC-independent manner. This includes small phosphorylated non-peptide antigens, such as those produced by cellular pathogens and cancers. The γδ TCR is associated with three CD3 dimeric subunits—CD3εγ, CD3εδ, and CD3ζζ—forming an octameric γδ TCR–CD3 complex. This complex plays a crucial role in the immune response by triggering the phosphorylation of ITAMs within the cytoplasmic tails of CD3 subunits upon antigen engagement, initiating downstream signaling events. The γδ TCR–CD3 complex is an attractive target for cancer immunotherapy due to its unique properties and effector functions. TCR δ protein is a component of the γδ T cell receptor (TCR), forming a heterodimer with TCR γ chain. This γδ TCR is expressed on γδ T cells, which are a unique subset of T cells with both adaptive and innate immune characteristics. Unlike αβ TCRs that primarily recognize peptide antigens presented by MHC molecules, γδ TCRs can recognize a diverse range of antigens in an MHC-independent manner. TCR δ, along with TCR γ, undergoes somatic recombination of V, D, and J gene segments to generate diversity. The γδ TCR-CD3 complex, which includes TCR γ, TCR δ, and CD3 subunits, plays a crucial role in antigen recognition and T cell activation. Upon antigen binding, the complex triggers the phosphorylation of ITAMs in the CD3 subunits, initiating downstream signaling pathways that lead to T cell proliferation, differentiation, and effector functions. This makes the γδ TCR-CD3 complex an attractive target for cancer immunotherapy, as it can provide broad protective immune responses against various infections and tumors.

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SKU: 1274420893

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4.2 ★★★★★
Based on 20 reviews
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Product Reviews
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Verified Purchase
Denise Boyd
Cuba, US
★★★★★ 4
Great toy but if your dog is an aggressive chewer, please think twice.
Color: Crinkle Chicken (Brown), Size: Large
I received this on May 23rd and on June 8th, after playing with this thing every day, our recently acquired 36 lb dog finally ripped it open and got out all the plastic and the squeaky part. Lily Belle will miss you, chicken. Lily loooooved this toy! She'd toss it in the air, chew on it, pull it with her teeth etc. but as much as she loved it, we won't replace it. It's just not durable enough for her. If your dog is an aggressive chewer, you might want to try a different toy. I hate that this lasted just a smidge over two weeks because Lily seemed to truly enjoy this toy. RIP, squeaky chicken!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 9, 2026
L
Verified Purchase
Literally doesn’t work
Battle Creek, US
★★★★★ 5
Great Value Toy
Color: Crinkle Duck (Blue), Size: Large, Color: Crinkle Duck (Blue), Size: Large
This toy has been one of my dog’s absolute favorites. He gets excited every time he sees it and will carry it around the house, toss it in the air, and keep himself entertained for a long time. The shape and texture seem perfect for him, and it quickly became one of his go-to toys over everything else in his basket. What I really like is that it holds up reasonably well for the price. It’s definitely not indestructible, and after a lot of play, it will sometimes start to rip—usually around the feet first since that’s where my dog tends to grab and chew the most. But honestly, considering how affordable it is, I don’t mind replacing it when needed. It’s inexpensive enough that rebuying feels worth it because he genuinely loves it that much. I’d rather keep buying a toy he is obsessed with than spend more on something that just sits untouched. It’s fun, cute, and keeps him happy, which is what matters most. Overall, I’d definitely recommend it for dogs who love plush toys and playful chewing.
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Reviewed in the United States on April 28, 2026
L
Verified Purchase
Lady B
Lake Worth, US
★★★★★ 5
Best affordable squeaker toy
Color: Crinkle Chicken (Brown), Size: Large, Color: Crinkle Chicken (Brown), Size: Large
my dog is obsessed with this toy, this has became his new comfort toy and after having this for about four months the legs are falling off but it’s very durable. The squeaker also moved from the head of the chicken to the body of the chicken but that’s after it was played with every single day. I love that it has two squeakers and it’s the perfect toy for my dog.
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Reviewed in the United States on May 6, 2026
A
Verified Purchase
Amazon Customer
Fort Morgan, US
★★★★★ 5
My dogs favorite toy EVER
Color: Crinkle Chicken (Brown), Size: Large
I have a Belgian Malinois who loves any and every toy, but this one is definitely her favorite. She will walk around the house constantly carrying it in her mouth, which is honestly adorable to watch. The squeakers only lasted a couple of months, but I don’t really consider that a downside—I’m kind of grateful they didn’t last forever given how much she plays with it. It still remains one of her most-loved toys even without them. My only word of caution is that if you work from home, this toy makes a lot of crinkling noise. And I mean A LOT. It’s great for keeping the dog entertained, but it can definitely get a little frustrating for humans trying to focus or take calls. Overall, it’s been a big hit in our house and easily one of her favorite toys.
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Reviewed in the United States on June 8, 2026
A
Verified Purchase
Amazon Customer
Pawtucket, US
★★★★★ 5
Super cute
Color: Bunny (Mauve), Size: Small
Super cute and fuzzy. Definitely perfect size for a puppy and not too loud. The fur is very soft and the nose is sown on not a hard piece that can be chewed on. Very good quality too.
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Reviewed in the United States on June 3, 2026

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