SKU: 14685423751

FGF-6 Protein, Human

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Description

FGF-6 Protein, HumanProduct Specification Species Human Synonyms Fibroblast growth factor 6, FGF 6, Heparin secretory transforming protein 2 (HST 2; HSTF 2), Heparin binding growth factor 6 (HBGF 6) Accession P10767 Amino Acid Sequence Gly41 Ile208 Expression System E. coli Molecular Weight 14 15 kDa (Reducing) Purity >95% by SDS PAGE, >90% by HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4

Product Specification


Species Human
Synonyms Fibroblast growth factor 6, FGF-6, Heparin secretory-transforming protein 2 (HST-2; HSTF-2), Heparin-binding growth factor 6 (HBGF-6)
Accession P10767
Amino Acid Sequence

Gly41-Ile208

Expression System E.coli
Molecular Weight

14-15 kDa (Reducing)

Purity >95% by SDS-PAGE, >90% by HPLC.
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, pH7.4

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.

Reference

Genes & Dev. 1997;11(16):2040-2051.
Nat Commun. 2020;11(1):1421.

Background

Fibroblast growth factor 6 (FGF-6), also designated as HST2 or HBGF-6, is a secreted peptide growth factor belonging to the paracrine FGF subfamily. The FGF6 gene, located on human chromosome 12p13, encodes an 18.9 kDa protein that exhibits the highest expression in skeletal muscle and myogenic progenitor cells throughout embryonic development and adulthood. FGF-6 binds preferentially to fibroblast growth factor receptor 4 (FGFR4) with heparan sulfate proteoglycan co-receptor dependency, triggering downstream signaling through the MAPK/ERK1/2 and PI3K/AKT pathways.Functionally, FGF-6 operates as a dose-dependent regulator of myogenesis, promoting satellite cell proliferation at high concentrations and initiating myogenic differentiation via calcineurin-dependent pathways at lower concentrations. Beyond muscle physiology, FGF-6 exhibits pleiotropic functions in bone remodeling, iron homeostasis, thermogenesis, and oncogenesis, harboring both regenerative and tumorigenic activities.
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SKU: 14685423751

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Brian Diez
Charlottesville, US
★★★★★ 4
Good Quality
Size: 11, Color: White
Nice looking shoe. Slides on easy. My only feedback would be I wish the toe box was a bit wider and the heel a bit higher. It's a good shoe overall. I would buy again.
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Reviewed in the United States on April 10, 2025
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carl mazaleski
Massapequa, US
★★★★★ 5
Fit
Size: 11.5 Wide, Color: Cognac
Comfortable and affordable
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Reviewed in the United States on May 14, 2026
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The Product Connoisseur
Alexandria, US
★★★★★ 3
Classy pair that look great but don’t last
Size: 12, Color: Black, Size: 12, Color: Black
Great shoe. Slip on is easy and the shoes are comfortable and classy. Ten months later and the bottom has holes and didn’t last.
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Reviewed in the United States on March 30, 2025
J
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Jon
Carnegie, US
★★★★★ 5
Love it
Size: 11, Color: Black
Almost the perfect travel shoe. Goes well with both casual and formal attire. Walked like a million steps with this in Japan, SEA, etc. only thing it probably can't do is probably hiking. Otherwise the leather feels really high quality, and the shoe slips on without much fuss. I'd describe the style as: a dressed-up Converse
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Reviewed in the United States on March 22, 2026
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jack brice
Birmingham, US
★★★★★ 1
Would not every buy marc Joseph shoes ever
Size: 11 Wide, Color: Black
The marc Joseph shoes did not hold up had a blow out rightside of shoes had the shoes for about two weeks when my wife noticed and say that not good.i buy Cohen shoes and Clarke shoes
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Reviewed in the United States on May 7, 2026

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