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Description
S-RMab® IDO1/Indoleamine 2,3-dioxygenase Recombinant Rabbit mAb (S-259-62)Product Specification Host Rabbit Antigen IDO1 Indoleamine 2,3 dioxygenase Synonyms Indoleamine pyrrole 2,3 dioxygenase, IDO, INDO Immunogen Recombinant Protein Location Cytoplasm Accession P14902 Clone Number S 259 62 Antibody Type Recombinant mAb Application WB, ICC, ICFCM, IHC Reactivity Hu Purification Protein A Concentration 0. 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin
Product Specification
| Host | Rabbit |
| Antigen | IDO1/Indoleamine 2,3-dioxygenase |
| Synonyms | Indoleamine-pyrrole 2,3-dioxygenase, IDO, INDO |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | P14902 |
| Clone Number | S-259-62 |
| Antibody Type | Recombinant mAb |
| Application | WB, ICC, ICFCM, IHC |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:200-1:1000 | null |
| ICC | 1:100 | null |
| ICFCM | 1:100 | null |
Background
Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer.
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