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Description
PLK1 Recombinant Rabbit mAb (SDT-R062)Product Specification Host Rabbit Antigen PLK1 Synonyms STPK13 Immunogen N A Location Nucleus Accession P53350 Clone Number SDT R062 Antibody Type Rabbit mAb Application WB, IHC P, IP Reactivity Hu Purification Protein A Concentration 1. 0 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application dilution
Product Specification
| Host | Rabbit |
| Antigen | PLK1 |
| Synonyms | STPK13 |
| Immunogen | N/A |
| Location | Nucleus |
| Accession | P53350 |
| Clone Number | SDT-R062 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1.0 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:200 | null |
| WB | 1:20000 | null |
| IP | 1:100 | null |
Background
PLK1 is a serine/threonine kinase that plays a pivotal role in cell division. Its dysregulation is tightly linked to malignant transformation. In human cancers, there is growing evidence coupling PLK1 activity to tumor development, progression, and therapy resistance. PLK1 is overexpressed in various cancers, and its expression levels correlate with poor prognosis. During cell division, the most prominent network or chestrating mitotic onset consists of the PLK1-Aurora A-Cyclin B1/CDK1 feedback loop. In this respect, PLK1 activity is reported to be a critical prerequisite for mitotic entry.
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