Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 23 - Jul 28
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Phospho-EGFR (Tyr1173) Recombinant Rabbit mAb (S-1187-106)Product Specification Host Rabbit Antigen Phospho EGFR (Tyr1173) Synonyms Epidermal growth factor receptor; Proto oncogene c ErbB 1; Receptor tyrosine protein kinase erbB 1; ERBB; ERBB1; HER1; EGFR Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P00533 Clone Number S 1187 106 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample A431 treated with 200 ng ml EGF for 10 minutes Predicted
Product Specification
| Host | Rabbit |
| Antigen | Phospho-EGFR (Tyr1173) |
| Synonyms | Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1; EGFR |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P00533 |
| Clone Number | S-1187-106 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | A431 treated with 200 ng/ml EGF for 10 minutes |
| Predicted Reactivity | Mq |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
Phospho-EGFR (Tyr1173) is a phosphorylated form of the epidermal growth factor receptor (EGFR), a 170 kDa transmembrane receptor tyrosine kinase that plays a crucial role in cell signaling. When EGFR binds to its ligands, such as EGF, it undergoes dimerization and autophosphorylation, activating multiple downstream signaling pathways. Phosphorylation at Tyr1173 is particularly important as it provides a docking site for proteins like the tyrosine phosphatase SHP-1, which can modulate EGFR activity and downstream signaling. This site is also involved in the MAP kinase signaling pathway, which regulates cell growth, survival, and transformation. Abnormal regulation of EGFR, including phosphorylation at Tyr1173, is often associated with various cancers, making it a key target for therapeutic interventions.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy