SKU: 30208131129

Pure Spermidine - 1 mg, 180 capsules

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Description

Pure Spermidine - 1 mg, 180 capsulesSpermidine A Vital Compound for Cellular Repair and Longevity* Replenish spermidine*1 Boost autophagy*1 3 Mimic the positive effects of fasting*2 Optimize healthy aging*1 5 View Certificate of Analysis Purely Sourced: Made from purified wheat germ extract, precisely standardized for maximum spermidine content. Never Synthetic: Formulated exclusively from natural sources to provide food grade spermidinefree from synthetic spermidine trihydrochloride.

Spermidine - A Vital Compound for Cellular Repair and Longevity* 

  • Replenish spermidine*1
  • Boost autophagy*1-3
  • Mimic the positive effects of fasting*2
  • Optimize healthy aging*1-5

View Certificate of Analysis

  • Purely Sourced: Made from purified wheat germ extract, precisely standardized for maximum spermidine content.
  • Never Synthetic: Formulated exclusively from natural sources to provide food-grade spermidine—free from synthetic spermidine trihydrochloride.
  • Ideal Dosage: Each capsule delivers "the just right dose" of spermidine to support healthy autophagy activation.*1-3
  • Trusted Quality Since 1988: USA manufactured, 3rd-party lab tested, GMP certified for your peace of mind.

What Makes Ours Better?

  • Longevity Focused: We leverage cutting-edge advancements in aging research to formulate products that address the fundamental causes of aging.*
  • Triple Lab Tested: Every product is tested three times by independent 3rd-party labs to ensure we meet the highest standards.
  • Complete Transparency: In an industry flooded with fake supplements, we stand apart by publishing our 3rd-party lab test results. We’re committed to showing you exactly what’s in every bottle, so you can feel confident in what you’re putting into your body.
  • USA Manufacturing Excellence: Made in FDA-regulated, GMP-certified facilities in the USA for the highest quality and safety standards.*
  • 100-Day Risk-Free Guarantee: We stand behind our products. Not satisfied? Reach out to our Santa Barbara, CA office for a full refund within 100 days – no hassle, no questions.

Spermidine is a naturally occurring polyamine compound present in all living organisms, derived from the amino acid ornithine. It plays a crucial role in youthful cellular processes and uniquely activates autophagy, the body’s cellular cleanup mechanism. Autophagy facilitates the breakdown and recycling of old and damaged cellular components, helping to rejuvenate cell structure and function.*1-3

While fasting and caloric restriction are the most well-known methods for activating autophagy, supplementing with spermidine provides a groundbreaking alternative that mimics the benefits of fasting, effectively “turning on” autophagy without the need for caloric restriction.*1-3

ProHealth Pure Spermidine offers a pure, vegan, and non-GMO source of this powerful compound, supporting the body’s natural cellular renewal processes. For best results, we recommend taking 1 to 3 capsules with your evening meal to jump-start an overnight fast or with breakfast to extend the benefits of your overnight fasting period.*2

Spermidine - A Vital Compound for Cellular Repair and Longevity*

Boost autophagy (cellular clean-up)*1-3
Spermidine acts directly on our cells to restore them to a healthy state. It works by inducing autophagy - a process that keeps our cells working more efficiently by removing damaged parts of the cell and repairing cellular function.*1-3

Mimic the positive effects of fasting*2
When we fast - extend the time between meals - spermidine levels increase, activating cellular repair and restoration processes that promote healthy aging. Supplementing with spermidine can mimic key aspects of the fasting state, allowing your body to experience its healthy aging benefits.*2

Optimize healthy aging*
Spermidine intake is associated with a healthy life span and may support up to nine hallmarks of aging. A research study showed that people who consume more spermidine are likely to live longer, compared to those who consume lower levels.  And research shows that supplementing with spermidine can help preserve the length of telomeres - the regions of DNA that shorten as you age.*1,4

Order now and join the 200,000+ people who trust ProHealth

Ingredients:

  • Wheat germ extract: (Triticum aestivum): A concentrated food source of spermidine.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

1 Hofer et al. Nat Aging. 2022 Dec 22;2(12):1112-1129. 
2 Hofer et al. Nat Cell Biol. 2024 Sep;26(9):1571-1584. 
3 Madeo et al. Autophagy. 2019 Jan;15(1):165–168. 
4 Kiechl et al. Am J Clin Nutr. 2018 Aug 1;108(2):371-380. 
5 Wirth et al. Geroscience. 2021 Apr;43(2):673-690.

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 180
Amount Per Serving %DV
Spermidine (From Wheat Germ Extract) 1 mg †
† Daily Value (DV) not established

REV.09.24

Nu-FLOW® is a registered trademark of Ribus Inc.

  • OTHER INGREDIENTS: Vegetable cellulose (capsule), microcrystalline cellulose, Nu-Flow® (rice hulls).
  • CONTAINS: Wheat.
  • SUGGESTED DAILY USE: Take one (1) to three (3) capsules with your last meal to start an overnight fast, or with breakfast to extend its benefits, or as directed by your healthcare professional.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper evident seal is broken or missing.
  • CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.
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SKU: 30208131129

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4.1 ★★★★★
Based on 10 reviews
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A
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A. Menon
West Palm Beach, US
★★★★★ 5
Illuminating perspective on the evolution of thought of the political leadership in Iran
Iran's Grand Strategy is a well timed overview of the why's of Iran's leadership political outlook and the historical path that has taken them to where they are today. The book was written before this war has erupted between Israel/US and Iran and so discusses the political economy under the leadership of Khomeini and Khamenei, but it gives enough substance to allow the reader to translate this historical perspective into an understanding of the internal dynamics of Iran in this moment, something that is probably largely absent from the political calculus of the US when it made its decision to join Israel's strike The book is a work of political science and the history that has defined it. As such it starts with the Iranian revolution, the background to it, the politics of that day (which was mixing both socialist a-religious political groups with a religious political agenda for which the latter seized power) and how the leadership never really had a popular mandate to rule the country but consolidated power after broad discontent. Iran was subsequently really shaped by its war with Iraq and in many ways was a war of attrition and opportunism to varying degrees through time. Nonetheless this war shaped the leaderships views of how to govern and how to frame their mandate which was as the saviour of the country which would have to sacrifice to endure. Iran was the subject of chemical warfare, for which there were no sanctions. The US was seen to have subsidized Saddam's war initiative which provided ideological substance for considering the US as an enemy. The relationship with Israel is also discussed and how Iran took up the mantle of support for Palestinians as the much of other parts of the Middle East focused on a more narrow self interest. This period was define by the author's term Sacred Defence, where existential survival was the message for enlisting. This is also highlighted as how the regime became more defined by its security needs as determined by the IRGC rather than by the clerics. This phase shift has stuck and the author views much of the religious rationalization of political strategy as founded in security calculations from leadership of the IRGC along with the Ayatollah. This is why much major business is controlled by the IRGC and the Khamenei's son was projected to become the next leader despite hereditary rule as being anathema to an Islamic republic. The author discusses how Iran repurposed itself as an axis of resistance to US hegemony that was founded in its wartime survival mentality. That this largely has not carried over to its population despite it being fundamentally entrenched in much of the IRGC. The various democratic initiatives pursued often backfired as the leadership was voted against in parliamentary elections, though the real influence on politics was minimal given the Ayatolla's dominance. This transition of interest of the population and obstinance of the leadership led to increasing civil unrest and a pick up in protesting in the aftermath of the regional overthrows that took place in Egypt, Libya etc.. These episodes also further highlighted how the nuclear program remained a core asset for preventing external influence given Libya's voluntary decision to cease its nuclear program did Ghaddafi no favors at the time of being overthrown. These highlight the self preservation of Iran's leadship as being independent of the will of the people which is why there is fundamental disillusionment in the country of the future based on the existing political economy. The author spends time on the concept of Forward Defense, a guerilla warfare type mentality of the leadership to fill the power vacuum that emerged with the fall of Saddam. This had other regional reverberations in increased skirmishes with Israel through proxies and some religions fighting in Sunni/Shiite with Saudi and the Houthis as an example. Thus in the pursuit of resistance Iran ignored the externalities to regional players which have forced more isolation on Iran which is stuck in the past in its mindset and increasingly alone. This Forward Defense is part of the reason why settling on nuclear deals and having any mutual grounds for trust with the US has been impossible, with both sides having legitimate reasons for complete absence of trust. As such where we are today though not inevitable was never impossible. Overall this book was written for context of Iran's political calculus with no prediction for the current conflict but it is useful for that goal. I feel more informed for reading it and have a better perspective on why the views are as they are. It is also hard to deny there has been significant pettiness mixed with deep conflicting strategic interests that have led to the frictions on display in the last 20 years. Core interests will be difficult to reconcile, but the pettiness adding further barriers is getting more absurd by the day. Nonetheless if one wants to get some healthy perspective this is a solid book.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 26, 2026
S
Verified Purchase
STEPHEN SWENERTON
West Palm Beach, US
★★★★★ 5
EXCELLENT RESOURCE
Format: Hardcover
OUTSTANDING SUMMARY OF THE EVENTS LEADING UP TO THE CURRENT VERY UNFORTUNATE SITUATION. I USED IT AS MY PRIMARY SOURCE FOR A CLASS I AM TEACHING ON THE SUBJECT OF THE WAR IN IRAN.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 24, 2026
M
Verified Purchase
Max
Waukegan, US
★★★★★ 5
an excellent reference book
Format: Hardcover
At a time when the U.S. and Israel’s military operation against Iran has become one of the most important issues on the global agenda, this is an excellent reference book that summarizes the historical development of events and provides valuable context for better understanding what is happening today.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 11, 2026
M
Verified Purchase
Mr. Flex
Bozeman, US
★★★★★ 5
Great for better understanding Iran's strategic perspectives
Format: Hardcover
The book moves through the growth of Iran's strategic history since the 1979 revolution. By the time it gets to the last 100 pages its very interesting as far as understanding Iran's perspective. Also found it chilling how foreboding many parts were in light of what is happening right now
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 2, 2026
H
Verified Purchase
Hassan Nasir
Alexandria, US
★★★★★ 5
Great book to understand Iran's strategy in a historical context
Nasr provides a solid understanding of Iran both in contemporary and historical context. It makes the case clear what and how Iran is thinking. Reading it at the time of Us-Israel and Iran war helped make sense of the news media, which often follows shallow analysis.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 27, 2026

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