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Description
CMTM6 Recombinant Rabbit mAb (S-2013-4)Product Specification Host Rabbit Antigen CMTM6 Synonyms CKLF like MARVEL transmembrane domain containing protein 6; Chemokine like factor superfamily member 6; CKLFSF6 Immunogen Synthetic Peptide Location Endosome, Cell membrane Accession Q9NX76 Clone Number S 2013 4 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample MDA MB 231, Raji, BxPC 3, HCT 116, HDLM 2 Purification Protein A Concentration 0. 5 mg
Product Specification
| Host | Rabbit |
| Antigen | CMTM6 |
| Synonyms | CKLF-like MARVEL transmembrane domain-containing protein 6; Chemokine-like factor superfamily member 6; CKLFSF6 |
| Immunogen | Synthetic Peptide |
| Location | Endosome, Cell membrane |
| Accession | Q9NX76 |
| Clone Number | S-2013-4 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | MDA-MB-231, Raji, BxPC-3, HCT 116, HDLM-2 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:500 | Hu |
Background
CMTM6, also known as CKLF-like MARVEL transmembrane domain-containing 6, is a transmembrane protein encoded by the CMTM6 gene, located on chromosome 3. It belongs to the CKLF-like MARVEL transmembrane domain-containing family, which consists of nine members and is involved in various biological processes including autoimmune diseases, cardiovascular diseases, the male reproductive system, hematopoiesis, and cancer development. CMTM6 has been identified as a critical regulator of PD-L1, an immune checkpoint protein. It stabilizes PD-L1 on the cell surface by preventing its lysosome-mediated degradation and ubiquitination, thereby enhancing the ability of tumor cells to evade immune surveillance. High expression of CMTM6 is associated with poor prognosis in several types of cancer, such as glioma, hepatocellular carcinoma, and triple-negative breast cancer.
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