SKU: 99798902218

Mouse Anti-Rat CD45R Antibody (S-3303)

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Description

Mouse Anti-Rat CD45R Antibody (S-3303)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; Ptprc Location Cell membrane, Synapse Accession P04157 Clone Number S 3303 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Rt Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date

Product Specification


Host Mouse
Antigen CD45
Synonyms Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; Ptprc
Location Cell membrane, Synapse
Accession P04157
Clone Number S-3303
Antibody Type Mouse mAb
Isotype IgG2b,k
Application FCM
Reactivity Rt
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Background

CD45R is a critical splice variant of the CD45 protein, belonging to the receptor-type protein tyrosine phosphatase (RPTP) family. It is primarily expressed on the surface of B cells, monocytes, and certain T cell subsets. As a transmembrane glycoprotein, its extracellular region contains domains (A, B, C) encoded by variable exons, forming diverse isoforms (e.g., CD45RA, CD45RB). These domain variations influence glycosylation patterns and ligand-binding properties. The core function of CD45R lies in its intracellular phosphatase domain, which specifically dephosphorylates the C-terminal inhibitory tyrosine residues of Src family kinases (such as Lck and Fyn). This action positively regulates the initiation and activation threshold of lymphocyte receptor signaling pathways, playing a vital role in B cell development, activation, and the fine-tuning of immune responses. Changes in its expression pattern often serve as markers for lymphocyte differentiation and activation status (e.g., CD45RA+ denotes naive T cells), holding significant value in immunology research and the clinical diagnosis of immune-related diseases.

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SKU: 99798902218

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4.8 ★★★★★
Based on 16 reviews
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Verified Purchase
TheFaceLadyG
Carnegie, US
★★★★★ 5
One of the Most Useful Skincare Products I Own
Title: One of the Most Useful Products for Mature Skin — Smooths, Protects, and Works Beautifully Under Makeup At 52 with post-menopausal dry, mature skin, I’m always looking for products that don’t just sit on the surface, but actually improve how my skin looks and behaves throughout the day. This surprised me in the best way. This is not a treatment product, and it’s important to set that expectation upfront. This is a barrier-supporting, smoothing balm, and when you use it for what it is, it performs exceptionally well. The texture is where it really wins. It’s a solid balm stick, but it glides effortlessly without dragging or pulling on the skin, which is critical for more delicate, mature areas. It melts just enough on contact and leaves behind a smooth, lightweight, conditioned finish that feels nourishing without being greasy or heavy. From a formulation standpoint, this is built around silicones and emollients that give an immediate soft-focus effect, combined with oils and butters that help reinforce the moisture barrier. There’s also adenosine for long-term wrinkle support and collagen extract for conditioning, though this is not going to rebuild collagen or act like a corrective serum. What it does do extremely well is improve the appearance of the skin instantly. It softens fine lines, reduces that dry, crepey look that can show up midday, and adds just enough slip and hydration to make the skin look healthier and more refined. Where I really love this is under makeup. It creates a smooth, hydrated base that helps foundation sit better and prevents it from catching on dry areas. It doesn’t pill, it doesn’t break anything down, and it adds that subtle cushion that mature skin really benefits from. I’ve also used it over makeup for touch-ups, and it works just as well without disturbing what’s underneath. This has quickly become one of those products I keep within reach because it’s so practical. It’s not about transformation — it’s about maintenance, comfort, and immediate visual improvement, which, for mature skin, is often exactly what you need. No irritation for me, and it layers seamlessly with the rest of my routine.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 5, 2026
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Verified Purchase
DETRA JOHNSON
Lexington, US
★★★★★ 5
Consistency is the key
This product is amazing. You have to keep in mind that it doesn’t give instant results. However, consistent use will reveal wonders. I use my whole stick before I started to see results. When my stick was gone, is when I looked in the mirror and I was shocked. My forehead was tighter and lifted. My under eye bags had disappeared, and my eyes looked tighter. My skin was just so youthful looking. So I was like OK!! I need to order another one, I swear I didn’t think it was working at all until the sticker was gone. And I just woke up one morning and noticed a huge difference. I wonder if the changes will last?
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Reviewed in the United States on May 25, 2026
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Verified Purchase
Amazon Customer
Chelsea, US
★★★★★ 4
The balm stick needs to roll all the way to the top
Overall I like the product itself I think its very moisturizing and it does seem to help the appearance of wrinkles however I think for the cost its pretty wasteful in the application. The rollup stops and there is still a ton of product on the bottle. I had to dig it out with my finger for a good 2 weeks worth of product I dont understand why it doesnt roll all the way to the top..
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Reviewed in the United States on June 1, 2026
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Verified Purchase
Donna G
Phoenix, US
★★★★★ 5
Seems like it provides good coverage
Size: 6 Fl Oz (Pack of 1)
I am very much liking this for the sunscreen properties. It should be noted that your face will be white and it's hard to meld into your natural skin tones. However I'm more concerned with something that works
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Reviewed in the United States on April 5, 2026
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Verified Purchase
Anarelys
West Palm Beach, US
★★★★★ 5
reliable everyday sunscreen
Size: 6 Fl Oz (Pack of 1)
this product goes on smoother than many mineral sunscreens I’ve tried and doesn’t leave an overly thick or greasy feeling on the skin. The protection lasts well during outdoor activities, and the water resistance makes it great for the beach, workouts, or long walks in the sun.
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Reviewed in the United States on May 20, 2026

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