SKU: 98644816813

Axl mFc Chimera Protein, Mouse

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Description

Axl mFc Chimera Protein, MouseProduct Specification Species Mouse Synonyms Axl, UFO, Tyro7, JTK11, ARK Accession Q00993 Amino Acid Sequence His20 Pro443, with C terminal Mouse IgG2a Fc

Product Specification


Species Mouse
Synonyms Axl, UFO, Tyro7, JTK11, ARK
Accession Q00993
Amino Acid Sequence His20-Pro443, with C-terminal Mouse IgG2a Fc HKDTQTEAGSPFVGNPGNITGARGLTGTLRCELQVQGEPPEVVWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVTGHSSQHSLQTPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHHLHVVSRQPTELEVAWTPGLSGIYPLTHCNLQAVLSDDGVGIWLGKSDPPEDPLTLQVSVPPHQLRLEKLLPHTPYHIRISCSSSQGPSPWTHWLPVETTEGVPLGPPENVSAMRNGSQVLVRWQEPRVPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVTAYTSAGDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPRAFSWPIEGRMDPEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK
Expression System HEK293
Molecular Weight 80-95kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Mouse Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Weinger J G. et al. (2011) Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis. J Neuroinflammation. 8: 49.

2、Linger R M. et al. (2010) Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors. Expert Opin Ther Targets. 14(10): 1073-1090.

3、Cavet M E. et al. (2010) Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB. Hypertension. 56(1): 105-111.

4、Rankin E B. et al. (2010) AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res. 70(19): 7570-7579.

Background

AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. Mature human Axl consists of a 426 aa extracellular domain (ECD) that contains two Ig-like domains and two fibronectin type III domains, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain that includes the tyrosine kinase domain. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. The receptor tyrosine kinase (RTK) AXL has been associated with poor prognosis in numerous malignancies and the emergence of therapy resistance. Upon binding to its ligand GAS6, AXL regulates cell signaling cascades and cellular communication between various components of the tumor microenvironment, including cancer cells, endothelial cells, and immune cells. Converging evidence points to AXL as an attractive molecular target to overcome therapy resistance and immunosuppression, supported by the potential of AXL inhibitors to improve ICI efficacy. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer.
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SKU: 98644816813

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Adrian
Lexington, US
★★★★★ 5
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Size: 5 Fl Oz (Pack of 1)
recently tried La Roche-Posay sunscreen and I’m really impressed! 🌞 The texture is lightweight, non-greasy, and absorbs quickly without leaving a white cast, which is a big plus for daily wear. It feels gentle on my skin and doesn’t clog pores, making it perfect for sensitive or acne-prone skin. I also love that it provides strong, broad-spectrum protection while still feeling breathable. Overall, it’s become my go-to sunscreen—I actually enjoy applying it every morning because it feels more like skincare than sunscreen. Definitely worth it! I would be honored if you would consider me to receive a PR package. I’d love the opportunity to try more of your products and create authentic content that highlights the benefits of La Roche-Posay skincare. Thank you so much for your time and consideration! Warm regards, Andrea Mohanlall
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Reviewed in the United States on September 4, 2025
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Bywater Mike
Charlottesville, US
★★★★★ 5
Goes on smooth with no white cast.
Size: 3 Fl Oz (Pack of 1)
This is excellent and disappears on the skin. Smooth as silk.
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Reviewed in the United States on May 10, 2026
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Carmen Suárez
Omaha, US
★★★★★ 4
It feels very good on the skin.
Size: 3 Fl Oz (Pack of 1)
I’ve been using this sunscreen for about a week now, and honestly, I’ve liked it even more than I expected. The skin on my face feels much softer and healthier, and one thing I’ve definitely noticed is that my dark circles are gradually looking a bit lighter and less tired. I love it because it doesn’t feel heavy, absorbs quickly, and doesn’t leave a greasy residue. I also like that it works well under makeup or just on its own for everyday use. For now, I’m giving it 4 stars because I haven’t been using it for very long yet and want to see more results, but so far, I definitely feel a difference in my skin. If I continue to see more positive changes, I’ll come back to update my review.
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Reviewed in the United States on May 30, 2026
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Diane P
San Leandro, US
★★★★★ 5
Blends nicely, is not greasy.
Size: 5 Fl Oz (Pack of 1)
Light, blends nicely into skin. Does a good job of blocking the sun. I will buy it again before the summer is over.
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Reviewed in the United States on May 21, 2026
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Aj
Belleville, US
★★★★★ 5
Feels like nothing!
Size: 3 Fl Oz (Pack of 1)
Fantastic! I never write reviews but this is incredible. Just as advertised it dries quickly, doesn’t feel oily and doesn’t leave marks. And the coverage is no joke in this AZ sun! Held up during Memorial Day weekend at the pool all day. Excellent all around!
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