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Description
cGAS Recombinant Rabbit mAb (S-708-15)Product Specification Host Rabbit Antigen cGAS Synonyms Cyclic GMP AMP synthase, cGAMP synthase, h cGAS, 2'3' cGAMP synthase, Mab 21 domain containing protein 1, C6orf150, MB21D1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession Q8N884 Clone Number S 708 15 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | cGAS |
| Synonyms | Cyclic GMP-AMP synthase, cGAMP synthase, h-cGAS, 2'3'-cGAMP synthase, Mab-21 domain-containing protein 1, C6orf150, MB21D1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | Q8N884 |
| Clone Number | S-708-15 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:500-1:2000 | |
| ICC | 1:500 |
Background
Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon response. It is part of the cGAS-STING DNA sensing pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes cGAMP synthesis. cGAMP then functions as a second messenger that binds to and activates the endoplasmic reticulum protein STING to trigger type-I IFNs production. Mice lacking cGAS are more vulnerable to lethal infection by DNA viruses and RNA viruses.[5][6] In addition, cGAS has been shown to be an innate immune sensor of retroviruses including HIV.
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