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Description
BD-5 Protein, HumanProduct Specification Species Human Synonyms Beta defensin 105; Beta defensin 5 (BD 5; DEFB 5); Defensin, beta 105; Accession Q8NG35 Amino Acid Sequence Gly28 Ile78 Expression System E. coli Molecular Weight 5 kDa (Reducing) Purity >95% by SDS PAGE. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM PB, 250mM NaCl, pH6. 5 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size
Product Specification
| Species | Human |
| Synonyms | Beta-defensin 105; Beta-defensin 5 (BD-5; DEFB-5); Defensin, beta 105; |
| Accession | Q8NG35 |
| Amino Acid Sequence | Gly28-Ile78 |
| Expression System | E.coli |
| Molecular Weight | 5 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM PB, 250mM NaCl, pH6.5 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Nature. 2003 Apr 3;422(6931):522-6. |
Background
Beta-defensin 5 is a member of the defensin family of antimicrobial peptides that play a crucial role in the innate immune system's defense against pathogens. It is primarily expressed in the gastrointestinal tract, where it contributes to maintaining the mucosal barrier integrity and protecting against microbial invasion. Beta-defensin 5 exhibits potent antimicrobial activity against a wide range of pathogens, including bacteria, fungi, and viruses, by disrupting their cell membranes. In addition to its direct antimicrobial effects, beta-defensin 5 also plays a role in modulating immune responses, promoting wound healing, and maintaining the balance of the gut microbiota.
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