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Description
TAG1/Contactin 2 His Tag Protein, HumanProduct Specification Species Human Synonyms Axonal glycoprotein TAG 1; axonin 1 cell adhesion molecule; Axonin 1; AXT; CNTN2; contactin 2 (axonal); contactin 2 (transiently expressed); Contactin2; Contactin 2; DKFZp781D102; FLJ37193; MGC157722; TAG1; TAG 1; TAX; TAX1; TAX 1; TAX1FLJ42746; Transient axonal glycoprotein 1; transiently expressed axonal glycoprotein Accession Q02246 Amino Acid Sequence Ser31 Asn1012, with C terminal His Expression System
Product Specification
| Species | Human |
| Synonyms | Axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; Axonin-1; AXT; CNTN2; contactin 2 (axonal); contactin 2 (transiently expressed); Contactin2; Contactin-2; DKFZp781D102; FLJ37193; MGC157722; TAG1; TAG-1; TAX; TAX1; TAX-1; TAX1FLJ42746; Transient axonal glycoprotein 1; transiently-expressed axonal glycoprotein |
| Accession | Q02246 |
| Amino Acid Sequence | Ser31-Asn1012, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 110-130kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 0.1M Arg, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Wolfer, D. and R. J. Giger (1994) Swissprot Accession # Q61330. 2.Hasler, T.H. et al. (1993) Eur. J. Biochem. 211:329. 3.Karagogeos, D. (2003) Front. Biosci. 8:s1304. |
Background
Contactin-2 is also known as CNTN2, TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, and is a member of the immunoglobulin superfamily. In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region.As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.
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