SKU: 95986887472

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)

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Description

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)Product Specification Host Rabbit Antigen Histone H3 (tri methyl K4) Synonyms H3K4me3 Location Nucleus Accession P68431 Clone Number S 4099 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ChIP Reactivity Hu, Ms, Rt Positive Sample HeLa, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12

Product Specification


Host Rabbit
Antigen Histone H3 (tri methyl K4)
Synonyms H3K4me3
Location Nucleus
Accession P68431
Clone Number S-4099
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC, ChIP
Reactivity Hu, Ms, Rt
Positive Sample HeLa, NIH/3T3, C6
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20°C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
ICC 1:500 Hu, Ms
ChIP 1:20-1:50 Hu

Background

Histone H3 lysine 4 trimethylation (commonly denoted as H3K4me3) is a crucial epigenetic modification on the tail of core histone H3 that plays a central role in regulating gene transcription. It is primarily catalyzed by histone methyltransferases from the COMPASS/COMPASS-like family (such as MLL1-4 and SET1A/B) and is specifically recognized by "reader" proteins containing PHD domains (e.g., Taf3 and ING family proteins). The genomic distribution of H3K4me3 is highly characteristic: it is strongly enriched at the promoter regions of actively transcribed genes, particularly near transcription start sites, marking a "primed for activation" state. This modification facilitates the formation of open chromatin structures and the assembly of the transcription initiation complex by recruiting chromatin remodelers, general transcription factors, and histone acetyltransferases, thereby positively regulating gene expression. H3K4me3 is essential for maintaining pluripotency in embryonic stem cells, cell fate determination, and processes such as learning and memory. Notably, its dysregulation—whether excessive or deficient—is closely associated with various developmental disorders and cancers (such as leukemia and breast cancer). Consequently, H3K4me3 is not only a vital biomarker in fundamental research but also a potential target for disease diagnosis and therapy.

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SKU: 95986887472

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Jusvette Sierra
Waukegan, US
★★★★★ 5
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Size: King (Pack of 2), Style: Soft, Configuration: Pillow
These pillows I’ve use for a while now are so fluffy and soft and comfortable and perfect for stomach and back sleepers They give gentle support and are easy to wash Great quality and also water resistance for the price
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Reviewed in the United States on April 2, 2026
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Barb
Massapequa, US
★★★★★ 4
Best for decorating. Not sleeping.
Size: King (Pack of 2), Style: Soft, Configuration: Pillow
These are perfect as inserts for decorative shams and the price was great. I don't think that I would ever want to use them for sleeping. They seem slightly lumpy and don't look they would last for very long with constant use.
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Reviewed in the United States on January 16, 2026
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Andy
San Leandro, US
★★★★★ 5
Great value, soft but still supportive – perfect for everyday use
Size: King (Pack of 2), Style: Soft, Configuration: Pillow
Really impressed with these pillows for the price. They’re soft but still provide decent support, and work well for both back and side sleeping. No weird smell and very comfortable overall. Definitely a great budget option! 👍
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Reviewed in the United States on March 31, 2026
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Suitu Wang
Belleville, US
★★★★★ 5
Great pillow
Size: King (Pack of 2), Style: Soft, Configuration: Pillow, Size: King (Pack of 2), Style: Soft, Configuration: Pillow
I love it! It’s very soft and comfortable. It provides strong support when I slept on it. Definitely outperforms other pillows at similar prices.
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Reviewed in the United States on April 12, 2026
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Amazon Customer
Pawtucket, US
★★★★★ 3
Very soft
Size: King (Pack of 2), Style: Soft, Configuration: Pillow
These don't maintain their shape well, I wish they were a bit firmer.
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Reviewed in the United States on April 3, 2026

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