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Description
Beta I tubulin Recombinant Rabbit mAb (S-3108-63)Product Specification Host Rabbit Antigen Beta I tubulin Synonyms Tubulin beta 1 chain; TUBB1 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession Q9H4B7 Clone Number S 3108 63 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample A204, HepG2, HT 29, HeLa, NIH 3T3, PC 12, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | Beta I tubulin |
| Synonyms | Tubulin beta-1 chain; TUBB1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | Q9H4B7 |
| Clone Number | S-3108-63 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | A204, HepG2, HT-29, HeLa, NIH/3T3, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:4000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
Background
Beta I tubulin, the most neuron-enriched β-tubulin isoform encoded by TUBB1, is a ~50 kDa globular protein that heterodimerizes with α-tubulin to assemble neuron-specific microtubule arrays, stabilizing axonal and dendritic cytoskeletons through GTP-dependent head-to-tail polymerization and interaction with microtubule-associated proteins; its unique C-terminal tail undergoes reversible glutamylation and detyrosination to regulate motor-protein trafficking, synaptic plasticity and axonal transport, while missense mutations (e.g., V180A, R215W) disrupt microtubule dynamics and cause a spectrum of neurodevelopmental disorders termed “tubulinopathies” characterized by simplified gyral pattern, microcephaly and intellectual disability, making Beta I tubulin a critical determinant of neuronal morphology and human brain development.
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