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Description
CD300a/LMIR1 His Tag Protein, HumanProduct Specification Species Human Synonyms CD300A,CLM 8,CMRF 35 H9,CMRF35 H9,CMRF35 H,IRC1 IRC2,IgSF12,IRp60,CMRF35H,IGSF12,LMIR1 Accession Q9UGN4 1 Amino Acid Sequence Leu18 Gln178, with C terminal His Expression System HEK293 Molecular Weight 25 43kDa (Reducing) Purity 95% by SDS PAGE&95% by SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4
Product Specification
| Species | Human |
| Synonyms | CD300A,CLM-8,CMRF-35-H9,CMRF35-H9,CMRF35-H,IRC1/IRC2,IgSF12,IRp60,CMRF35H,IGSF12,LMIR1 |
| Accession | Q9UGN4-1 |
| Amino Acid Sequence | Leu18-Gln178, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 25-43kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE&＞95% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Clark, G.J. et al. (2009) Trends Immunol. 30:209. Bachelet, I. et al. (2006) J. Allergy Clin. Immunol. 117:1314. Munitz, A. et al. (2006) J. Allergy Clin. Immunol. 118:1082. |
Background
LMIR1, also known as CD300a, CMRF-35H, IRp60, CLM-8, and MAIR-I, is a 60 kDa glycoprotein member of the immunoglobulin superfamily. In human, LMIR1 is expressed on peripheral blood eosinophils, mast cells, neutrophils, plasmacytoid dendritic cells, and various T cell subsets.Antibody cross‑linking of LMIR1 induces phosphorylation of tyrosine residues in the cytoplasmic domain. This leads to the recruitment of phosphatases SHIP, SHP-1, and SHP-2 and inhibition of NK cell, eosinophil, and mast cell activation. Cross‑linking of LMIR1 to other surface proteins such as SCF R or Fc epsilon RI on mast cells, Fc gamma RIIA on neutrophils, or CCR3 on mast cells and eosinophils inhibits downstream signaling from those receptors. LMIR1 cross‑linking also limits the in vivo activities of these cells with a subsequent reduction of allergic inflammation symptoms.CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs).
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