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Description
TSG101 Recombinant Rabbit mAb (S-1868-76)Product Specification Host Rabbit Antigen TSG101 Synonyms Tumor susceptibility gene 101 protein; ESCRT I complex subunit TSG101 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Nucleus, Endosome Accession Q99816 Clone Number S 1868 76 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample MCF7, K562, Jurkat, HeLa, C2C12, mouse heart, PC 12, COS 7 Purification Protein A Concentration
Product Specification
| Host | Rabbit |
| Antigen | TSG101 |
| Synonyms | Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Nucleus, Endosome |
| Accession | Q99816 |
| Clone Number | S-1868-76 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | MCF7, K562, Jurkat, HeLa, C2C12, mouse heart, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
TSG101 (Tumor Susceptibility Gene 101) is an essential 380-amino-acid human protein that contains an N-terminal UEV (ubiquitin E2 variant) domain and a proline-rich C-terminal region, functioning as the core subunit of the ESCRT-I complex that drives membrane scission events during multivesicular body formation, viral budding and cytokinesis by recognizing mono-ubiquitinated cargo via its UEV domain and coupling it to downstream ESCRT machinery, while its misregulation or truncation, originally identified in a screen for tumor suppressor genes, is linked to neoplastic transformation, defective cell cycle checkpoints and chromosomal instability.
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