SKU: 94700246412

IL-3R alpha/CD123 His Tag Protein, Canine

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Description

IL-3R alpha/CD123 His Tag Protein, CanineProduct Specification Species Canine Synonyms CD123 antigen; CD123; hIL3Ra; hIL 3Ra; IL 3 R alpha; IL 3 receptor subunit alpha; IL3R alpha; IL 3R alpha; IL 3R subunit alpha; IL3R; IL3RA; IL 3Ra; IL 3R alpha; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor, alpha (low affinity); interleukin 3 receptor subunit alpha; MGC34174 Accession XP_038305195. 1 Amino Acid Sequence Ser33 Asp315, with C terminal His Expression System HEK293 Molecular Weight 43 55kDa

Product Specification


Species Canine
Synonyms CD123 antigen; CD123; hIL3Ra; hIL-3Ra; IL-3 R alpha; IL-3 receptor subunit alpha; IL3R alpha; IL-3R alpha; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; MGC34174
Accession XP_038305195.1
Amino Acid Sequence Ser33-Asp315, with C-terminal His
Expression System HEK293
Molecular Weight 43-55kDa (Reducing)
Purity >95% by SDS-PAGE &>95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference
1. LIU, KEQIANG, ZHU, MENGRU, HUANG, YAO, et al. CD123 and its potential clinical application in leukemias [J]. Life sciences,2015,122(1):59-64.

Background

Interleukin-3 receptor α (IL-3Rα) is the α subunit of the ligand-specific IL-3R and initiates intracellular signaling in response to IL-3. The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. IL-3 amplifies proinflammatory signaling and cytokine storm in murine sepsis models. In vitro, IL-3 stimulation promoted IL-3Rα proteasomal degradation dependent on RNFT2 (RING finger transmembrane-domain containing protein 2, also TMEM118), and we identified IL-3Rα lysine 357 as a ubiquitin acceptor site. Researches identify RNFT2 as a negative regulator of IL-3Rα and show a potential role for the RNFT2/IL-3Rα/IL-3 axis in regulating innate immune responses in the lung.

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SKU: 94700246412

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nate71
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★★★★★ 5
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I LOVE my bag! I use it all the time. It looks tiny but holds a lot.
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Reviewed in the United States on April 16, 2026
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joanne avon
New York, US
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★★★★★ 5
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Decent size. I bought it as a gift for my SIL and she loves it.😊 Denim is good for everyday use.
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