SKU: 94301161299

GLI1 Recombinant Rabbit mAb (S-2678-117)

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Description

GLI1 Recombinant Rabbit mAb (S-2678-117)Product Specification Host Rabbit Antigen GLI1 Synonyms Zinc finger protein GLI1; Glioma associated oncogene; Oncogene GLI; GLI; GLI1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P08151 Clone Number S 2678 117 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample A673 Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol,

Product Specification


Host Rabbit
Antigen GLI1
Synonyms Zinc finger protein GLI1; Glioma-associated oncogene; Oncogene GLI; GLI; GLI1
Immunogen Synthetic Peptide
Location Cytoplasm, Nucleus
Accession P08151
Clone Number S-2678-117
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu
Positive Sample A673
Purification Protein A
Concentration 1 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu

Background

GLI1 (Glioma-associated oncogene homolog 1) is an 110 kDa zinc-finger transcription factor of the GLI family that acts as the primary activator of the Hedgehog (Hh) signaling pathway: in response to Hh ligands, smoothened-mediated inhibition of the Patched receptor is relieved, allowing GLI1 to accumulate in the nucleus where it binds GACCACCCA-like motifs to drive expression of target genes that regulate cell proliferation, stem-cell maintenance, differentiation, and tissue patterning during embryogenesis; in adults, tight control of GLI1 is essential because its dysregulation—through activating mutations, ligand overproduction, or loss of suppressors such as PTCH1 or SUFU—promotes oncogenic transcriptional programs implicated in basal-cell carcinoma, medulloblastoma, pancreatic, breast, and other cancers, making GLI1 both a biomarker of pathway activity and a therapeutic target for small-molecule inhibitors like vismodegib and arsenic trioxide.

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SKU: 94301161299

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4.8 ★★★★★
Based on 6 reviews
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Product Reviews
S
Verified Purchase
Shawn Hughes
Lowell, US
★★★★★ 4
used solely as start watch for yacht racing: interface is good (lacks sync feature). Great value
on foredeck of a sailboat, lines and sails love to snag on stuff, especially wrist watches. Have had three torn from my wrist in 18 months. Two went overboard. I even tried to purchase super-strong spring-bars (pins that secure the band), but it was torn off again. PRO: great (intuitive, quick) interface for setting the countdown starting time, and option to repeat or count up. easy to read display CON: No sync feature: in countdown timer mode, would allow adjusting the running countdown to the nearest minute. Delay in switching modes: had left it in time-of-day mode and heard a starting signal, immediately switched to Timer mode and pressed start button, but it did not start the timer. On switching modes, it takes nearly a second for Timer mode to be operational, so need to wait until display comes on before trying to use it. Time-of-day is not visible in Timer Mode, if it was, previous issue would rarely occur. No Power down feature: my previous watch had an option to shut off the LCD display (and any audible alarms). Since I only use the watch about 100 hours (1%) of the year, this greatly extended the battery life. All that said, the dedicated sailing watches all cost two to ten times as much with the lower cost options having poor reviews on quality. For now, I'll buy these (Timex Ironman Essential 30) and just expect to loose one on average once a year.
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Reviewed in the United States on June 3, 2024
G
Verified Purchase
Glenn
Omaha, US
★★★★★ 5
Great watch - Nice large display!!
After my old Timex Ironman finally died after 21 years of reliable service (may it rest in peace after 4 replacement bands and 5 replacement batteries!!), I decided Timex deserved another sale from me! So I went surfing on the Timex website. So many Timex Ironman watches to choose from! But this one stood out for two reasons. 1) It has a nice simple design without a lot of "noise". 2) A nice large readable display. So I took the plunge! Indeed, Timex has definitely improved on their Ironman watches in the last 21 years. Most notably, the Indiglo light has greatly improved. It used to just light up the background. Now, it brightly lights up the actual digits which makes it undeniably readable without any eye strain. Another great improvement are in the set features. While the older models could only be set forward (in other words, if you went past your set point, you would need to go all the way around), this model lets you set forward and backward (so if you go too far, you can step back without going around). I don't understand one of the reviewers saying that the watch is too small. The face is quite large. The band may seem narrow in proportion to the watch face, but not excessively so. The band is 19mm wide and fits me just fine. Highly recommended!!
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Reviewed in the United States on November 12, 2017
R
Verified Purchase
RS
Boise, US
★★★★★ 5
Like it so far after 2 weeks of swimming.
Like it so far after 2 weeks of swimming. Have been careful nio to press buttons underwater. I Like the large numerals, backlight, countdown timer, stopwatch and alarm. My last Timex 1440 lasted 10 years before the battery was low enough that the backlight was too weak to see at night. I replaced the battery on it but did not seal the o ring well enough with silicon grease so it leaked and quit working. I also had also replaced the band once.
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Reviewed in the United States on September 9, 2024
A
Verified Purchase
Andrei
Lake Worth, US
★★★★★ 5
Good product.
A very nice and comfortable watch. Display is easy to read (I have poor eyesight). The menu is simple and intuitive. Fast delivery to Israel.
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Reviewed in the United States on October 1, 2025
F
Verified Purchase
francisco
Draper, US
★★★★★ 5
Little Small On The Wrist
Really cool timepiece, been loving timex a lot recently, this is me coming over Casio/G-shocks. Although it is a bit smaller on the wrist it still looks very nice and I really love the gray and like green color contrast. Really easy to read the time as well.
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Reviewed in the United States on May 27, 2024

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