SKU: 93967516043

APC Mouse Anti-Human CD3 Antibody (S-R476)

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Description

APC Mouse Anti-Human CD3 Antibody (S-R476)Product Specification Host Mouse Antigen CD3 Synonyms T cell surface glycoprotein CD3 epsilon chain; T cell surface antigen T3 Leu 4 epsilon chain; T3E; CD3E Location Cell membrane Accession P07766 Clone Number S R476 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human peripheral blood Leukocyte Purification Protein G Concentration 0. 2 mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA,

Product Specification


Host Mouse
Antigen CD3ε
Synonyms T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; T3E; CD3E
Location Cell membrane
Accession P07766
Clone Number S-R476
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample human peripheral blood Leukocyte
Purification Protein G
Concentration 0.2 mg/ml
Conjugation APC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Hu

Background

CD3ε is a subunit of the CD3 complex, which is a critical component of the T-cell receptor (TCR) complex on T cells. Together with CD3γ, CD3δ, and CD3ζ, it forms the TCR-CD3 complex that plays a vital role in coupling antigen recognition to intracellular signaling pathways. This complex is essential for T cell activation, proliferation, and differentiation. CD3ε contains an extracellular immunoglobulin domain, a transmembrane region, and a cytoplasmic tail with an immunoreceptor tyrosine-based activation motif (ITAM). Upon antigen recognition, the ITAMs in CD3ε are phosphorylated, initiating downstream signaling cascades that lead to T cell activation. Additionally, CD3ε interacts with other signaling molecules like Lck and Nck through its unique motifs, further modulating T cell responses. Its importance in T cell function makes CD3ε a target for immunotherapies, including cancer treatments and autoimmune disease management.

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SKU: 93967516043

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★★★★★ 5
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Reviewed in the United States on July 30, 2024
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Martial M.
New York, US
★★★★★ 5
Good
Very good quality
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★★★★★ 5
Classy gift for men.
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Mary
Draper, US
★★★★★ 5
Little pricey, but worth it
Very nice product. Creates a clean look on my fiances night stand rather than having everything all over the place. I like the little compartment with the door, its nice for putting things out of sight. The coin compartment is nice as well. The curve of the bottom makes it easy to get the coins out. I do think its a little pricey for what it is, but i still feel it was worth it to organize the clutter.
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Reviewed in the United States on June 17, 2020
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I. Gonzalez
Battle Creek, US
★★★★★ 5
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