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Description
ARID1A Recombinant Rabbit mAb (S-440-62)Product Specification Host Rabbit Synonyms AT rich interactive domain containing protein 1A, ARID domain containing protein 1A, B120, BRG1 associated factor 250, BRG1 associated factor 250a, Osa homolog 1 (hOSA1), SWI like protein, SWI SNF complex protein p270, SWI SNF related, matrix associated, actin dependent regulator of chromatin subfamily F member 1, hELD, C1orf4, OSA1, SMARCF1 Immunogen Recombinant Protein Location Nucleus Accession O14497
Product Specification
| Host | Rabbit |
| Synonyms | AT-rich interactive domain-containing protein 1A, ARID domain-containing protein 1A, B120, BRG1-associated factor 250, BRG1-associated factor 250a, Osa homolog 1 (hOSA1), SWI-like protein, SWI/SNF complex protein p270, SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1, hELD, C1orf4, OSA1, SMARCF1 |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | O14497 |
| Clone Number | S-440-62 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:2000 | null |
Background
ARID1A is part of the large ATP-dependent chromatin remodelling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. It is thought that the protein confers specificity to the SWI/SNF complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. ARID1A has been commonly found mutated in gastric cancers, ovarian clear cell carcinoma,[9] and pancreatic cancer. In breast cancer distant metastases acquire inactivation mutations in ARID1A not seen in the primary tumor, and reduced ARID1A expression confers resistance to different drugs such as trastuzumab and mTOR inhibitors.
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