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Description
ERCC1 Recombinant Rabbit mAb (SDT-R056)Product Specification Host Rabbit Antigen ERCC1 Synonyms DNA excision repair protein ERCC 1 Immunogen N A Location Nucleus Accession P07992 Clone Number SDT R056 Antibody Type Rabbit mAb Application IHC P, ICC Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied
Product Specification
| Host | Rabbit |
| Antigen | ERCC1 |
| Synonyms | DNA excision repair protein ERCC-1 |
| Immunogen | N/A |
| Location | Nucleus |
| Accession | P07992 |
| Clone Number | SDT-R056 |
| Antibody Type | Rabbit mAb |
| Application | IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | null |
| ICC | 1:50 | null |
Background
ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
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