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Description
Invivo anti-mouse IL-23 (p19) Recombinant mAbProduct Specification Host Rat Antigen IL 23 (p19) Synonyms Interleukin 23 subunit alpha; IL 23 subunit alpha; IL 23 A; Interleukin 23 subunit p19 (IL 23p19); SGRF; IL23A Location Secreted Accession Q9NPF7P29460 Clone Number S 2754 Antibody Type Rat mAb Isotype Rat IgG1,k Application WB, Neutralization Reactivity Ms Purification Protein G Concentration 5 mg ml Purity >95% by SDS PAGE Endotoxin <2EU mg Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rat |
| Antigen | IL-23 (p19) |
| Synonyms | Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19 (IL-23p19); SGRF; IL23A |
| Location | Secreted |
| Accession | Q9NPF7、P29460 |
| Clone Number | S-2754 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG1,k |
| Application | WB, Neutralization |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <2EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
Background
Interleukin-23 (IL-23) is a heterodimeric cytokine composed of a p19 subunit and a p40 subunit. The p19 subunit is unique to IL-23, while the p40 subunit is shared with IL-12. IL-23 plays a crucial role in the immune system, particularly in the regulation of T cell responses. It is involved in the differentiation and maintenance of Th17 cells, a subset of T helper cells that produce pro-inflammatory cytokines such as IL-17 and IL-22. These Th17 cells are essential for host defense against extracellular pathogens but can also contribute to chronic inflammation and autoimmune diseases when dysregulated. IL-23 signaling occurs through the IL-23 receptor complex, which includes IL-23R and IL-12Rβ1 subunits, and activates downstream pathways like JAK-STAT, leading to the production of various inflammatory mediators. Due to its involvement in immune-mediated inflammatory diseases, IL-23 has become a target for therapeutic interventions, with several biologics targeting the p19 subunit or the IL-23 receptor being developed and used in the treatment of conditions such as psoriasis, Crohn’s disease, and other autoimmune disorders.
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