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Description
Anti-EGFR Monoclonal Antibody(Cetuximab)Product Specification Host Human Antigen EGFR Synonyms Epidermal growth factor receptor, Proto oncogene c ErbB 1, Receptor tyrosine protein kinase erbB 1, ERBB, ERBB1, HER1 Location Cell membrane Accession P00533 Clone Number S SC017 Antibody Type Recombinant mAb Isotype IgG1,k Application FCM, Blocking of EGFR signaling Functional assays Purification Protein A Concentration 2 mg ml Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Human |
| Antigen | EGFR |
| Synonyms | Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, ERBB, ERBB1, HER1 |
| Location | Cell membrane |
| Accession | P00533 |
| Clone Number | S-SC017 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1,k |
| Application | FCM, Blocking of EGFR signaling Functional assays |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ELISA | 0.305-5000 ng/ml | |
| FCM | 1:20000 |
Background
Cetuximab is a monoclonal antibody that inhibits the epidermal growth factor receptor (EGFR) which is present on the surface of some cancer cells. Cetuximab binds to the receptor, preventing epidermal growth factor (EGF) from binding to it and stimulating growth of the cancer cells. Cetuximab is used to treat squamous cell cancer of the head and neck. Cetuximab is commonly used alongside chemotherapy as a first line approach to cancer that has spread or is recurring. It is also used alongside radiation therapy in localized disease. Patients with metastatic colorectal cancer that expresses EGFR may be treated with cetuximab in combination with chemotherapy or cetuximab may be given as a single therapy to patients who have failed to respond to irinotecan- and oxaliplatin-based regimens.
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Exchange/Return Notes
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